Chemistry:Perazine

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Short description: Typical antipsychotic medication


Perazine
Perazine.svg
Clinical data
AHFS/Drugs.comInternational Drug Names
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UNII
KEGG
ChEBI
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Chemical and physical data
FormulaC20H25N3S
Molar mass339.50 g·mol−1
3D model (JSmol)
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Perazine (Taxilan) is a moderate-potency typical antipsychotic of the phenothiazine class. It is quite similar to chlorpromazine, and acts as a dopamine antagonist. A 2014 systematic review compared it with other antipsychotic drugs:

Perazine versus other antipsychotic drugs for schizophrenia[1]
Summary
The number, size and reporting of randomized controlled perazine trials are insufficient to present firm conclusions about the properties of this antipsychotic. It is possible that perazine is associated with a similar risk of extrapyramidal side effects as some atypical antipsychotics but this is based on few comparisons of limited power.[1]

Synthesis

Perazine synthesis:[2][3] Patents:[4][5] Alternate source:[6][7]

Phenothiazine-10-propionitrile [1698-80-2] (1) is treated with a mixture of acid and alcohol giving Methyl phenothiazinepropionate, CID:368244 (2). Heating with 1-methylpiperazine (3) gives the amide [91508-47-3] (4). Reduction of this last by means of diborane yields Perazine (5).

See also

References

  1. 1.0 1.1 "Perazine for schizophrenia". The Cochrane Database of Systematic Reviews 1 (1): CD002832. January 2014. doi:10.1002/14651858.CD002832.pub3. PMID 24425538. http://www.cochrane.org/CD002832/SCHIZ_perazine-for-schizophrenia. 
  2. Hromatka, O.; Sauter, F.; Schlager, L. H. (1957). "Untersuchungen über Phenthiazinderivate III: Über die Synthese von 10-(Piperazinoalkyl)-phenthiazinen". Monatshefte für Chemie. 88 (2): 193–201. doi:10.1007/BF00901625.
  3. Hromatka, O.; Stehlik, G.; Sauter, F. (1960). "Untersuchungen über Phenthiazinderivate, 12. Mitt.: Reaktionen zur Géwinnung von 10-(?-Methylpiperazinylpropyl)-phenthiazin". Monatshefte für Chemie 91 (1): 107–116. doi:10.1007/BF00903173.
  4. GB780193 idem Horclois Raymond Jacques, U.S. Patent 2,902,485 (1957 to Rhône-Poulenc).
  5. Anon., GB patent 901187 (1962 to Chemische Fabrik Promonta GmbH).
  6. Owen, Terence C. (1984). "Synthesis of perazine". Journal of Heterocyclic Chemistry. 21 (1): 265–266. doi:10.1002/jhet.5570210154.
  7. Brufani; Cesta; Filocamo; Lappa; Marta; Pomponi; Meroni; Pagella Farmaco, 1992, vol. 47, # 5 p. 585 – 597.

External links