Chemistry:UB-165
From HandWiki
Short description: Pharmaceutical drug
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| Formula | C13H15ClN2 |
| Molar mass | 234.724 g·mol−1 |
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UB-165 is a drug which acts as an agonist at neuronal nicotinic acetylcholine receptors being a full agonist of the α3β2 isoform and a partial agonist of the α4β2* isoform. It is used to study the role of this receptor subtype in the release of dopamine and noradrenaline in the brain,[1][2] and has also been used as a lead compound to derive a number of other selective nicotinic receptor ligands.[3][4][5][6]
References
- ↑ "UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes". The Journal of Neuroscience 20 (8): 2783–91. April 2000. doi:10.1523/JNEUROSCI.20-08-02783.2000. PMID 10751429.
- ↑ "Nicotinic acetylcholine receptor-mediated [3H]dopamine release from hippocampus". The Journal of Pharmacology and Experimental Therapeutics 312 (3): 1298–304. March 2005. doi:10.1124/jpet.104.076794. PMID 15542623.
- ↑ "Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165". Journal of Medicinal Chemistry 45 (5): 1064–72. February 2002. doi:10.1021/jm010936y. PMID 11855986.
- ↑ "Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165". Journal of Medicinal Chemistry 45 (15): 3235–45. July 2002. doi:10.1021/jm020814l. PMID 12109907.
- ↑ "Synthesis of two fluoro analogues of the nicotinic acetylcholine receptor agonist UB-165". The Journal of Organic Chemistry 68 (6): 2475–8. March 2003. doi:10.1021/jo026698b. PMID 12636420.
- ↑ "Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity". Bioorganic & Medicinal Chemistry Letters 13 (17): 2825–8. September 2003. doi:10.1016/S0960-894X(03)00594-8. PMID 14611837.
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