Chemistry:Octodrine

From HandWiki
Short description: DMAA substitute
Octodrine
Octodrine.png
Clinical data
Other namesDMHA; Ottodrina; Vaporpac; Amidrine; 2-Aminoisoheptane; 2-Amino-6-methylheptane; 1,5-Dimethylhexylamine; 6-Methyl-2-heptylamine; 6-Methyl-2-heptanamine[1]
Routes of
administration
Oral, inhaled
ATC code
  • none
Legal status
Legal status
  • US: Unapproved "New Drug" (as defined by 21 U.S. Code § 321(p)(1)). Use in dietary supplements, food, or medicine is unlawful; otherwise uncontrolled.[2]
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC8H19N
Molar mass129.247 g·mol−1
3D model (JSmol)
  (verify)

Octodrine (also known as Vaporpac or DMHA) is a stimulant drug whose pharmacology was studied in a dozen animal studies from the 1940s through the 1970s. These studies found that octodrine can increase blood pressure and cardiac output in animals. The drug was previously approved for use by the FDA as an inhalant (i.e., Vaporpac and Tickle Tackle Inhaler) and in Germany as an oral agent as part of a multicomponent medication (i.e., Ambredin and Ordinal), but is no longer available.[3]

DMHA has also been found as an adulterant in sports supplements and is sold online as a designer drug.[3] [4]

Related designer drugs

References

  1. CID 10982 from PubChem
  2. "DMHA in Dietary Supplements". March 6, 2023. https://www.fda.gov/food/dietary-supplement-ingredient-directory/dmha-dietary-supplements. 
  3. 3.0 3.1 "Four experimental stimulants found in sports and weight loss supplements: 2-amino-6-methylheptane (octodrine), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylamylamine (1,3-DMAA) and 1,3-dimethylbutylamine (1,3-DMBA)". Clinical Toxicology 56 (6): 421–426. June 2018. doi:10.1080/15563650.2017.1398328. PMID 29115866. 
  4. "Designer Stimulants: What Athletes Should Know | USADA". 24 January 2019. https://www.usada.org/spirit-of-sport/education/designer-stimulants-what-athletes-should-know/.