Chemistry:5-IAI

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Short description: Chemical compound
5-IAI
5-iodo-2-aminoindane.svg
Clinical data
Pregnancy
category
  • ?
Routes of
administration
Oral, Insufflated, Rectal
ATC code
  • none
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC9H10IN
Molar mass259.090 g·mol−1
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

5-Iodo-2-aminoindane (5-IAI) is a drug which acts as a releasing agent of serotonin, norepinephrine, and dopamine.[1] It was developed in the 1990s by a team led by David E. Nichols at Purdue University.[2] 5-IAI fully substitutes for MDMA in rodents and is a putative entactogen in humans.[2] Unlike related aminoindane derivatives like MDAI and MMAI, 5-IAI causes some serotonergic neurotoxicity in rats, but is substantially less toxic than its corresponding amphetamine homologue pIA, with the damage observed barely reaching statistical significance.[1]

Legal status

Sweden's public health agency suggested classifying 5-IAI as a hazardous substance, on September 25, 2019.[3]

References

  1. 1.0 1.1 "[3H]monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues". European Journal of Pharmacology 200 (1): 9–16. July 1991. doi:10.1016/0014-2999(91)90659-E. PMID 1685125. 
  2. 2.0 2.1 "5-Iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamine". Pharmacology Biochemistry and Behavior 38 (1): 135–9. January 1991. doi:10.1016/0091-3057(91)90601-W. PMID 1826785. 
  3. "Tretton ämnen föreslås klassas som narkotika eller hälsofarlig vara" (in sv). Folkhälsomyndigheten. 25 September 2019. https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2019/september/tretton-amnen-foreslas-klassas-som-narkotika-eller-halsofarlig-vara/.