Chemistry:Lavoltidine
From HandWiki
Short description: Chemical compound
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| Routes of administration | Oral |
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| Formula | C19H29N5O2 |
| Molar mass | 359.474 g·mol−1 |
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Lavoltidine (INN,[1] USAN, BAN; previously known as loxtidine, code name AH-23,844) is a highly potent and selective H2 receptor antagonist which was under development by Glaxo Wellcome (now GlaxoSmithKline)[2] as a treatment for gastroesophageal reflux disease but was discontinued due to the discovery that it produced gastric carcinoid tumors in rodents.[3][4]
See also
- H2 receptor antagonist
- Sufotidine (analogous sequence in which a sulfonyl group replaces the hydroxyl group)
References
- ↑ "International Nonproprietary Names for Pharmaceutical Substances. Recommended International Nonproprietary Names (Rec. INN): List 30". WHO Drug Information (World Health Organization) 4 (3): 7. 1990. https://www.who.int/medicines/publications/druginformation/innlists/RL30.pdf. Retrieved 12 January 2016.
- ↑ "Drug Profile: Lavoltidine". Springer International Publishing AG. http://adisinsight.springer.com/drugs/800000092.
- ↑ Antacids and anti-reflux agents. Boca Raton: CRC Press. 1991. ISBN 0-8493-5444-7. https://books.google.com/books?id=MKxtXgtt5SIC&q=loxtidine&pg=PA250.
- ↑ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8. https://books.google.com/books?id=x2Su3GKCvtsC&q=lavoltidine&pg=PA4087.
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