Chemistry:Ricasetron

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Short description: Chemical compound
Ricasetron
Ricasetron.svg
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC19H27N3O
Molar mass313.445 g·mol−1
3D model (JSmol)
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Ricasetron (BRL-46470) is a drug which acts as a selective antagonist at the serotonin 5-HT3 receptor.[1] It has antiemetic effects as with other 5-HT3 antagonists,[2] and also has anxiolytic effects significantly stronger than other related drugs,[3] and with less side effects than benzodiazepine anxiolytics.[4][5] However, it has never been developed for medical use.

See also

References

  1. "BRL 46470 potently antagonizes neural responses activated by 5-HT3 receptors". Neuropharmacology 32 (8): 729–35. August 1993. doi:10.1016/0028-3908(93)90180-B. PMID 8413836. 
  2. "Prolonged anti-emetic activity and 5-HT3-receptor antagonism by BRL 46470 in conscious ferrets". The Journal of Pharmacy and Pharmacology 46 (6): 520–1. June 1994. doi:10.1111/j.2042-7158.1994.tb03843.x. PMID 7932054. 
  3. "BRL 46470A: a highly potent, selective and long acting 5-HT3 receptor antagonist with anxiolytic-like properties". Psychopharmacology 110 (3): 257–64. 1993. doi:10.1007/BF02251279. PMID 7831418. 
  4. "The effects of BRL 46470A, a novel 5-HT3 receptor antagonist, and lorazepam on psychometric performance and the EEG". British Journal of Clinical Pharmacology 35 (4): 395–9. April 1993. doi:10.1111/j.1365-2125.1993.tb04156.x. PMID 8485019. 
  5. "Absence of amnestic effect of an anxiolytic 5-HT3 antagonist (BRL 46470A) injected into basolateral amygdala, as opposed to diazepam". Behavioural Brain Research 59 (1–2): 141–5. December 1993. doi:10.1016/0166-4328(93)90160-R. PMID 8155281.