Chemistry:Ro60-0175

From HandWiki
Short description: Chemical compound
Ro60-0175
Ro60-0175.svg
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEBI
Chemical and physical data
FormulaC11H12ClFN2
Molar mass226.68 g·mol−1
3D model (JSmol)
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Ro60-0175 is a drug developed by Hoffmann–La Roche, which has applications in scientific research.[1][2] It acts as a potent and selective agonist for both the 5-HT2B and 5-HT2C serotonin receptor subtypes, with good selectivity over the closely related 5-HT2A subtype, and little or no affinity at other receptors.[3][4]

See also

References

  1. "The serotonin 2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination". Psychopharmacology 193 (3): 391–402. August 2007. doi:10.1007/s00213-007-0802-3. PMID 17473916. 
  2. "The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues". Neuropsychopharmacology 33 (6): 1402–12. May 2008. doi:10.1038/sj.npp.1301509. PMID 17653111. 
  3. "Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells". British Journal of Pharmacology 128 (1): 13–20. September 1999. doi:10.1038/sj.bjp.0702751. PMID 10498829. 
  4. "Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol- l-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine(2C) receptor agonist". The Journal of Pharmacology and Experimental Therapeutics 304 (3): 1209–16. March 2003. doi:10.1124/jpet.102.043489. PMID 12604698.