Chemistry:Perphenazine enanthate

Perphenazine enanthate
Clinical data
Trade names	Decentan Depot, Peratsin Enantaatti, Trilafon, Trilafon Enantato, Trilafon Enantat, Trilifan Retard
Other names	Perphenazine enantate
Routes of; administration	Intramuscular injection
Drug class	Typical antipsychotic
ATC code	N05AB03 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl heptanoate;
CAS Number	17528-28-8;
PubChem CID	62871;
DrugBank	DB14651;
ChemSpider	56601;
UNII	Z6RS3DKN8J;
KEGG	D08342;
Chemical and physical data
Formula	C28H38ClN3O2S
Molar mass	516.14 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCCC(=O)OCCN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl;
	InChI InChI=1S/C28H38ClN3O2S/c1-2-3-4-5-11-28(33)34-21-20-31-18-16-30(17-19-31)14-8-15-32-24-9-6-7-10-26(24)35-27-13-12-23(29)22-25(27)32/h6-7,9-10,12-13,22H,2-5,8,11,14-21H2,1H3; Key:PWEGQJCIAMJJHC-UHFFFAOYSA-N;

Short description: Typical antipsychotic medication

Perphenazine enanthate, sold under the brand name Trilafon Enantat among others, is a typical antipsychotic and a depot antipsychotic ester which is used in the treatment of schizophrenia and has been marketed in Europe.^[1]^[2]^[3]^[4]^[5]^[6] It is formulated in sesame oil and administered by intramuscular injection and acts as a long-lasting prodrug of perphenazine.^[2]^[3]^[4]^[5]^[6] Perphenazine enanthate is used at a dose of 25 to 200 mg once every 2 weeks by injection, with a time to peak levels of 2 to 3 days and an elimination half-life of 4 to 7 days.^[2]^[3]^[4]^[5]^[6]

References

↑ Swiss Pharmaceutical Society (2000). Swiss Pharmaceutical Society. ed. Index Nominum 2000: International Drug Directory. Taylor & Francis. pp. 811–. ISBN 978-3-88763-075-1. https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA811.
↑ ^2.0 ^2.1 ^2.2 "Intramuscular preparations of antipsychotics: uses and relevance in clinical practice". Drugs 63 (5): 493–512. 2003. doi:10.2165/00003495-200363050-00004. PMID 12600227.
↑ ^3.0 ^3.1 ^3.2 "Depot antipsychotic drugs. Place in therapy". Drugs 47 (5): 741–73. May 1994. doi:10.2165/00003495-199447050-00004. PMID 7520856.
↑ ^4.0 ^4.1 ^4.2 "Psychopharmacology and adverse effects of antipsychotic long-acting injections: a review". Br J Psychiatry Suppl 52: S13–9. November 2009. doi:10.1192/bjp.195.52.s13. PMID 19880912.
↑ ^5.0 ^5.1 ^5.2 "The pharmacokinetics of long-acting antipsychotic medications". Curr Clin Pharmacol 9 (3): 310–7. 2014. doi:10.2174/15748847113089990051. PMID 23343447.
↑ ^6.0 ^6.1 ^6.2 "History and therapeutic rationale of long acting antipsychotics". Curr Clin Pharmacol 9 (1): 39–52. February 2014. doi:10.2174/15748847113089990057. PMID 23343446.

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/Perphenazine enanthate. Read more

[SwissPharmaceuticalSociety2000-1] Swiss Pharmaceutical Society (2000). Swiss Pharmaceutical Society. ed. Index Nominum 2000: International Drug Directory. Taylor & Francis. pp. 811–. ISBN 978-3-88763-075-1. https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA811.

[pmid12600227-2] 2.0 ^2.1 ^2.2 "Intramuscular preparations of antipsychotics: uses and relevance in clinical practice". Drugs 63 (5): 493–512. 2003. doi:10.2165/00003495-200363050-00004. PMID 12600227.

[pmid7520856-3] 3.0 ^3.1 ^3.2 "Depot antipsychotic drugs. Place in therapy". Drugs 47 (5): 741–73. May 1994. doi:10.2165/00003495-199447050-00004. PMID 7520856.

[pmid19880912-4] 4.0 ^4.1 ^4.2 "Psychopharmacology and adverse effects of antipsychotic long-acting injections: a review". Br J Psychiatry Suppl 52: S13–9. November 2009. doi:10.1192/bjp.195.52.s13. PMID 19880912.

[pmid23343447-5] 5.0 ^5.1 ^5.2 "The pharmacokinetics of long-acting antipsychotic medications". Curr Clin Pharmacol 9 (3): 310–7. 2014. doi:10.2174/15748847113089990051. PMID 23343447.

[pmid23343446-6] 6.0 ^6.1 ^6.2 "History and therapeutic rationale of long acting antipsychotics". Curr Clin Pharmacol 9 (1): 39–52. February 2014. doi:10.2174/15748847113089990057. PMID 23343446.

[1]

[2]

[3]

[4]

[5]

[6]

v t e Antipsychotics (N05A)
Typical	Butyrophenones: Benperidol Bromperidol Droperidol Haloperidol^# Moperone Pipamperone Spiperone Timiperone Trifluperidol Diphenylbutylpiperidines: Fluspirilene Penfluridol Pimozide Phenothiazines: Acetophenazine Butaperazine Carphenazine (carfenazine)^‡ Chlorpromazine Cyamemazine Dixyrazine Fluphenazine Levomepromazine (methotrimeprazine) Mesoridazine Perazine Periciazine Perphenazine Piperacetazine Pipotiazine Prochlorperazine Promazine Sulforidazine Thiopropazate Thioproperazine Thioridazine Trifluoperazine Triflupromazine Thioxanthenes: Chlorprothixene Clopenthixol Flupentixol Tiotixene (thiothixene) Zuclopenthixol
Disputed	Benzamides: Amisulpride Levosulpiride Nemonapride Remoxipride^‡ Sulpiride Sultopride Tiapride Veralipride^‡ Butyrophenones: Melperone Tricyclics: Carpipramine Clocapramine Clorotepine Clotiapine Loxapine Mosapramine Others: Molindone
Atypical	Benzisoxazole/benzisothiazoles: Iloperidone Lurasidone Paliperidone Paliperidone palmitate Perospirone Risperidone^# Ziprasidone Butyrophenones: Lumateperone^† Phenylpiperazines/quinolinones: Aripiprazole Aripiprazole lauroxil Brilaroxazine^† Brexpiprazole Cariprazine Tricyclics: Asenapine Clozapine^# Olanzapine Quetiapine Zotepine Others: Blonanserin Pimavanserin Sertindole
Others	Azacyclonol Cannabidiol Oxypertine Reserpine Tetrabenazine
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

v t e Tricyclics
Classes	Acridine Anthracene Dibenzazepine Dibenzocycloheptene Dibenzodiazepine Dibenzothiazepine Dibenzothiepin Dibenzoxazepine Dibenzoxepin Phenothiazine Pyridazinobenzoxazine Pyridinobenzodiazepine Thioxanthene
Antidepressants (TCAs and TeCAs)	7-OH-Amoxapine Amezepine Amineptine Amitriptyline Amitriptylinoxide Amoxapine Aptazapine Azepindole Azipramine Batelapine Butriptyline Cianopramine Ciclazindol Ciclopramine Cidoxepin Clomipramine Cotriptyline Cyanodothiepin Demexiptiline Depramine (balipramine) Desipramine (desmethylimipramine) Desmethylclomipramine Desmethyltrimipramine Dibenzepin Dimetacrine Dosulepin (dothiepin) Doxepin Enprazepine Esmirtazapine Fantridone Fluotracen Hepzidine Homopipramol Imipramine Imipraminoxide Intriptyline Iprindole Ketipramine Litracen Lofepramine Losindole Loxapine Maprotiline Mariptiline Mazindol Melitracen Metapramine Mezepine Mianserin Mirtazapine Monometacrine Naranol Nitroxazepine Norbutriptyline Nordoxepin Northiaden (nordosulepin) Nortriptyline (noramitriptyline) Noxiptiline Octriptyline Opipramol Oxaprotiline Pipofezine Pirandamine Propizepine Protriptyline Quinupramine Setiptiline (teciptiline) Spiroxepin Tandamine Tampramine Tianeptine Tienopramine Trimipramine
Antihistamines	Azatadine Bisulepin Clobenzepam Cyproheptadine Dacemazine Deptropine Desloratadine Epinastine Etymemazine Fenethazine Hydroxyethylpromethazine Isopromethazine Isothipendyl Ketotifen Latrepirdine Loratadine Mebhydrolin Mequitazine Methdilazine Olopatadine Oxomemazine Phenindamine Pimethixene Promethazine Propiomazine Rupatadine Thiazinamium
Antipsychotics	Acetophenazine Alimemazine Amoxapine Asenapine Butaclamol Butaperazine Carfenazine (carphenazine) Carpipramine Chlorpromazine Chlorprothixene Ciclindole Citatepine Clocapramine Clomacran Clorotepine Clotiapine Clozapine Cyanothepin Doclothepin Docloxythepin Erizepine Flucindole Flumezapine Fluotracen Flupentixol Fluphenazine Gevotroline Homopipramol Isofloxythepin Levomepromazine/Methotrimeprazine Loxapine Lurasidone Maroxepin Meperathiepin Mesoridazine Metiapine Metitepine Metoxepin Mosapramine Naranol Octomethothepin Olanzapine Oxyclothepin Oxyprothepin Pentiapine Peradithiepin Perathiepin Perazine Perphenazine Periciazine Pinoxepin Piperacetazine Pipotiazine Piquindone Prochlorperazine Promazine Prothipendyl Quetiapine Savoxepin/Cipazoxapine Sulforidazine Tenilapine Thiethylperazine Thiopropazate Thioridazine Thiothixene Tilozepine Traboxopine Trifluoperazine Triflupromazine Trifluthepin Zotepine Zuclopenthixol
Anticonvulsants	Carbamazepine Dizocilpine Eslicarbazepine Eslicarbazepine acetate Etazepine Licarbazepine Oxcarbazepine Oxitriptyline Rispenzepine
Others	Adosopine Aminopromazine Atiprosin Beloxepin Benzoctamine Carvedilol Cidoxepin Cyclobenzaprine Damotepine Darenzepine Elanzepine Fluradoline Methylene blue Monatepil Nuvenzepine Oxetorone Perlapine P7C3 Pinadoline Pirenzepine Pirolate Pitrazepin Pizotifen Profenamine Serazapine Siltenzepine Telenzepine Tipindole Tropatepine Zolenzepine

Anonymous

Search

Chemistry:Perphenazine enanthate

Namespaces

More

Page actions

See also

References

Navigation

Navigation

Help

Translate

Wiki tools

Wiki tools

Anonymous

Search

Chemistry:Perphenazine enanthate

See also

References

Navigation

Wiki tools

Page tools

Other projects

Categories