Chemistry:AMG-36

From HandWiki
Short description: Chemical compound
AMG-36
AMG-36 Structure.svg
Identifiers
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC27H40O2
Molar mass396.615 g·mol−1
3D model (JSmol)
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AMG-36 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8-THC substituted with a cyclopentane group on the 3-position side chain. AMG-36 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.45 nM at CB1 vs 1.92 nM at CB2.[1][2]

See also

References

  1. "Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'". Journal of Medicinal Chemistry 46 (15): 3221–9. July 2003. doi:10.1021/jm020558c. PMID 12852753. 
  2. "C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols". Journal of Medicinal Chemistry 50 (17): 4048–60. August 2007. doi:10.1021/jm070121a. PMID 17672444.