Chemistry:Tynorphin

From HandWiki
Short description: Synthetic opioid chemical compound
Tynorphin
Tynorphin.svg
Clinical data
ATC code
  • None
Legal status
Legal status
  • In general: non-regulated
Identifiers
PubChem CID
ChemSpider
Chemical and physical data
FormulaC35H46N6O7
Molar mass662.788 g·mol−1
3D model (JSmol)

Tynorphin is a synthetic opioid peptide which is a potent and competitive inhibitor of the enkephalinase class of enzymes which break down the endogenous enkephalin peptides.[1] It specifically inactivates dipeptidyl aminopeptidase III (DPP3) with very high efficacy, but also inhibits neutral endopeptidase (NEP), aminopeptidase N (APN), and angiotensin-converting enzyme (ACE) to a lesser extent.[1] It has a pentapeptide structure with the amino acid sequence Val-Val-Tyr-Pro-Trp (VVYPW).

Tynorphin was discovered in an attempt to develop an enkephalinase inhibitor of greater potency than spinorphin.[1]

See also

References

  1. 1.0 1.1 1.2 "Characterization of tynorphin, a potent endogenous inhibitor of dipeptidyl peptidaseIII". Peptides 21 (4): 503–8. April 2000. doi:10.1016/S0196-9781(00)00174-1. PMID 10822105.