Chemistry:SR-16435
From HandWiki
Short description: Drug
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| Formula | C22H30N2O |
| Molar mass | 338.495 g·mol−1 |
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SR-16435 is a drug which acts as a potent partial agonist at both the μ-opioid receptor and nociceptin receptor. In animal studies it was found to be a potent analgesic, with results suggestive of reduced development of tolerance and increased activity against neuropathic pain compared to classic μ-selective agonists.[1][2][3]
See also
References
- ↑ "SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a novel mixed nociceptin/orphanin FQ/mu-opioid receptor partial agonist: analgesic and rewarding properties in mice". The Journal of Pharmacology and Experimental Therapeutics 320 (2): 934–43. February 2007. doi:10.1124/jpet.106.111997. PMID 17132815.
- ↑ "Activities of mixed NOP and mu-opioid receptor ligands". British Journal of Pharmacology 153 (3): 609–19. February 2008. doi:10.1038/sj.bjp.0707598. PMID 18059322.
- ↑ "Effects of spinally administered bifunctional nociceptin/orphanin FQ peptide receptor/μ-opioid receptor ligands in mouse models of neuropathic and inflammatory pain". The Journal of Pharmacology and Experimental Therapeutics 346 (1): 11–22. July 2013. doi:10.1124/jpet.113.203984. PMID 23652222.
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