Chemistry:Tiapamil
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| Other names | Dimeditiapramine; Ro 11-1781 |
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| Formula | C26H37NO8S2 |
| Molar mass | 555.70 g·mol−1 |
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Tiapamil (INN; also known as dimeditiapramine) is a calcium antagonist or calcium channel blocker.[1][2] It is an experimental drug that has never been marketed.[3]
Tiapamil has been described as an antianginal agent. It exhibits properties of anti-arrhythmic medications. These are medications that are used to treat unusually fast or irregular heartbeats. Examples of arrhytmthic conditions include atrial fibrillation, atrial flutter, and super-ventricular tachycardia.[4] Upon research, the drug shows promising effects on treatment of these condition. Research seeks to create a treatment with tiapamil in order to mitigate the side effects of the more commonly prescribed calcium antagonist and anti-hypertensive verapamil. The two drugs have similar properties; however, tiapamil appears to treat arrhythmic conditions without many of the hypotensive, negative inotropic, and negative chronotropic side effects. Tiapamil is a calcium channel blocker that acts on the slow calcium channels. It can treat ventricular arrhythmias to a higher degree than traditional calcium antagonists.
See also
References
- ↑ "Human electropharmacology of the calcium antagonist dimeditiapramine (Ro 11-1781) in coronary patients". Clinical Cardiology 2 (3): 212–216. June 1979. doi:10.1002/clc.4960020307. PMID 509799.
- ↑ "Antiarrhythmic effect of the calcium antagonist tiapamil (Ro 11-1781) by intravenous administration in patients with coronary heart disease". Clinical Cardiology 3 (6): 371–376. December 1980. doi:10.1002/clc.4960030603. PMID 6161729.
- ↑ "Tiapamil". AdisInsight. Springer Nature Switzerland AG. https://adisinsight.springer.com/drugs/800028673.
- ↑ "Dimeditiapramine (Ro 11-1781), a new calcium antagonist, in the management of supraventricular tachyarrhythmias in patients with acute myocardial infarction". Clinical Cardiology 2 (2): 131–134. April 1979. doi:10.1002/clc.4960020208. PMID 262567.
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