Chemistry:Clentiazem

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Clentiazem
Clentiazem structure.svg
Names
Preferred IUPAC name
(2S,3S)-8-Chloro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
Identifiers
3D model (JSmol)
ChemSpider
UNII
Properties
C22H25ClN2O4S
Molar mass 448.9629
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Clentiazem is a calcium channel blocker.[1]

It is a chlorine derivative of diltiazem.[2]

References

  1. "Pharmacodynamics and pharmacokinetics of clentiazem and diltiazem in closed-chest anesthetized dogs". Cardiovasc Drugs Ther 9 (5): 685–92. October 1995. doi:10.1007/BF00878551. PMID 8573551. 
  2. "Clentiazem and diltiazem preserve endothelium-dependent relaxation following global rat heart ischemia". Can J Cardiol 11 (9): 816–22. October 1995. PMID 7585280.