Chemistry:Proxibarbital

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Short description: Chemical compound
Proxibarbital
Proxibarbital.svg
Clinical data
Other namesProxibarbital, Centralgol, Ipronal, 5-Allyl-5-(β-hydroxypropyl)barbituric acid
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC10H14N2O4
Molar mass226.232 g·mol−1
3D model (JSmol)
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Proxibarbital (Ipronal) is a barbiturate derivative synthesized in 1956. It has anti-anxiety properties and is, in contrast to most barbiturates, almost without hypnotic action.[1]

It was also used in the treatment of migraine headaches in a similar manner to butalbital.[2]

Valofane isomerises to Proxibarbal in vivo.

References

  1. (in polish) Chemia leków, podręcznik dla studentów farmacji i farmaceutów. Warszawa, Poland. 2008. ISBN 978-83-200-3652-7. 
  2. "[Migraine therapy by enzyme induction with proxibarbital]" (in German). Therapie der Gegenwart 115 (12): 2088–103. December 1976. PMID 14412.