Chemistry:Aceperone
From HandWiki
Short description: Chemical compound
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| Other names | Acetabuton; R 3248 |
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| Formula | C24H29FN2O2 |
| Molar mass | 396.506 g·mol−1 |
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| Melting point | 97 to 100 °C (207 to 212 °F) [1] |
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Aceperone is a neuroleptic drug of the butyrophenone class. It is an α-noradrenergic blocking drug developed by Janssen Pharmaceutica in the 1960s.[1]
Aceperone has been used as a tool in the study of the biochemical basis of learning. Although aceperone does not block learning per se, it blocks access to an attentional mechanism by which animals ‘tune in’ to the relevant visual dimension when learning a visual discrimination task[2][3] at doses below those that affect general behaviour.[4]
References
- ↑ 1.0 1.1 Janssen PA, "Alkoxylamino and alkoxycarbonylamino derivatives of 1(aroylalkyl)-4-arylpiperidines.", BE patent 606849, published 1961
- ↑ "A new approach to the role of noradrenaline in learning: problem-solving in the marmoset after alpha-noradrenergic receptor blockade". Pharmacology, Biochemistry, and Behavior 14 (6): 849–55. June 1981. doi:10.1016/0091-3057(81)90373-7. PMID 6114497.
- ↑ "Further consideration of the learning impairment after aceperone in the marmoset: effects of the drug on shape and colour discrimination and on an alternation task". Pharmacology, Biochemistry, and Behavior 18 (5): 701–4. May 1983. doi:10.1016/0091-3057(83)90009-6. PMID 6222386.
- ↑ "The effect of dopamine and noradrenaline blockade on amphetamine-induced behaviour in the marmoset". Psychopharmacology 62 (1): 41–5. March 1979. doi:10.1007/BF00426033. PMID 155838.
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