Chemistry:Cod-THC
From HandWiki
Short description: Synthetic chemical compound
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| Chemical and physical data | |
| Formula | C40H49NO6 |
| Molar mass | 639.833 g·mol−1 |
| 3D model (JSmol) | |
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Cod-THC (Codeine Δ9-tetrahydrocannabinol carbonate) is a synthetic codrug formed by linking tetrahydrocannabinol with codeine via a carbonate bridge. It is well absorbed orally and shows superior analgesic effects in animal studies compared to a simple mixture of the two drugs.[1][2][3]
See also
References
- ↑ ""Breaking bud": the effect of direct chemical modifications of phytocannabinoids on their bioavailability, physiological effects, and therapeutic potential". Organic & Biomolecular Chemistry 21 (18): 3715–3732. May 2023. doi:10.1039/d3ob00068k. PMID 36825573.
- ↑ Holtman JR, Crooks PA, Dhooper HK, "Novel synergistic opioid-cannabinoid codrug for pain management.", US patent 2008/0176885, published 24 July 2008, assigned to University of Kentuckyand Insys Therapeutics Inc.
- ↑ "Improving the Use of Drug Combination through the Codrug Approach". Prodrugs and Targeted Delivery: Towards Better ADME Properties.. Wiley. 2011. pp. 345–383 (374–376). ISBN 978-3-527-63318-0.
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