Chemistry:PF-03550096

From HandWiki
Short description: Chemical compound
PF-03550096
PF-03550096.svg
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC19H28N4O4
Molar mass376.457 g·mol−1
3D model (JSmol)

PF-03550096 is a drug that acts as a potent agonist for the CB2 cannabinoid receptor, with good selectivity over CB1 having Ki values of 7nM at CB2 and 1500nM at CB1. It was originally developed by Pfizer in 2008 as a medication for irritable bowel syndrome,[1] but has only progressed to animal studies.[2]

See also

References

  1. Ando K, et al, "Benzimidazolone Derivatives", WO patent 2008032164, published 20 March 2008, assigned to Pfizer Products Inc.
  2. "Pharmacological evaluation of a novel cannabinoid 2 (CB2) ligand, PF-03550096, in vitro and in vivo by using a rat model of visceral hypersensitivity". Journal of Pharmacological Sciences 106 (2): 219–24. February 2008. doi:10.1254/jphs.FP0071599. PMID 18270474.