Chemistry:Arachidonylcyclopropylamide

From HandWiki
Arachidonylcyclopropylamide
Arachidonylcyclopropylamide.svg
Names
Preferred IUPAC name
(5Z,8Z,11Z,14Z)-N-(Cyclopropyl)icosa-5,8,11,14-tetraenamide
Other names
ACPA
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
Properties
C23H37NO
Molar mass 343.555 g·mol−1
Solubility in other solvents soluble in ethanol, chloroform, THF and DMSO
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N (what is ☑Y☒N ?)
Infobox references
Tracking categories (test):

Arachidonylcyclopropylamide (ACPA) is a synthetic agonist of the cannabinoid receptor 1 (CB1R). ACPA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R) (Ki = 2.2 nM for CB1R; Ki = 700 nM for CB2R).[1]

References

  1. Hillard, CJ (1999). "Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)". The Journal of Pharmacology and Experimental Therapeutics 289 (3): 1427–33. PMID 10336536.