Biology:PRDM2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

PR domain zinc finger protein 2 is a protein that in humans is encoded by the PRDM2 gene.

Function

This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.

Interactions

PRDM2 has been shown to interact with Estrogen receptor alpha and Retinoblastoma protein.

Further reading

• "Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3". Gene 163 (2): 329–30. Oct 1995. doi:10.1016/0378-1119(95)00420-B. PMID 7590293. 
• "cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene". European Journal of Biochemistry 235 (3): 471–9. Feb 1996. doi:10.1111/j.1432-1033.1996.00471.x. PMID 8654390. 
• "Physical mapping of the retinoblastoma interacting zinc finger gene RIZ to D1S228 on chromosome 1p36". Genomics 34 (1): 119–21. May 1996. doi:10.1006/geno.1996.0249. PMID 8661032. 
• "The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter". The Journal of Biological Chemistry 272 (5): 2984–91. Jan 1997. doi:10.1074/jbc.272.5.2984. PMID 9006946. 
• "Transcriptional repression mediated by the PR domain zinc finger gene RIZ". The Journal of Biological Chemistry 272 (42): 26360–6. Oct 1997. doi:10.1074/jbc.272.42.26360. PMID 9334209. 
• "RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis". Cancer Research 58 (19): 4238–44. Oct 1998. PMID 9766644. 
• "The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3130–5. Mar 2000. doi:10.1073/pnas.050015697. PMID 10706618. 
• "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3491–6. Mar 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D. 
• "Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily". Cancer Research 61 (22): 8094–9. Nov 2001. PMID 11719434. 
• "Nucleotide alteration of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukemia". The Tohoku Journal of Experimental Medicine 196 (3): 193–201. Mar 2002. doi:10.1620/tjem.196.193. PMID 12002276. 
• "Frameshift mutations of RIZ, but no point mutations in RIZ1 exons in malignant melanomas with deletions in 1p36". Oncogene 21 (19): 3038–42. May 2002. doi:10.1038/sj.onc.1205457. PMID 12082534. 
• "Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia". British Journal of Haematology 119 (4): 940–8. Dec 2002. doi:10.1046/j.1365-2141.2002.03972.x. PMID 12472571. 
• "Biallelic inactivation of the RIZ1 gene in human gastric cancer". Oncogene 22 (44): 6954–8. Oct 2003. doi:10.1038/sj.onc.1206403. PMID 14534544. 
• "Inactivation of a histone methyltransferase by mutations in human cancers". Cancer Research 63 (22): 7619–23. Nov 2003. PMID 14633678. 
• "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. Aug 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B. 
• "Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability". World Journal of Gastroenterology 10 (18): 2719–22. Sep 2004. doi:10.3748/wjg.v10.i18.2719. PMID 15309726. 
• "The Zn-finger domain of RIZ protein promotes MCF-7 cell proliferation". Cancer Letters 215 (2): 229–37. Nov 2004. doi:10.1016/j.canlet.2004.05.014. PMID 15488642. 
• "A deletion polymorphism in the RIZ gene, a female sex steroid hormone receptor coactivator, exhibits decreased response to estrogen in vitro and associates with low bone mineral density in young Swedish women". The Journal of Clinical Endocrinology and Metabolism 89 (12): 6173–8. Dec 2004. doi:10.1210/jc.2004-0403. PMID 15579774. 

External links

• PRDM2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.