Biology:NFYB

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.

Function

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.

Interactions

NFYB has been shown to interact with:

• CEBPZ,
• CNTN2,
• Myc, and
• TBP

Further reading

• "Repression mechanisms of the I-A beta gene of the major histocompatibility complex.". Immunobiology 198 (1–3): 249–63. 1998. doi:10.1016/s0171-2985(97)80045-9. PMID 9442396. 
• "The molecular biology of the CCAAT-binding factor NF-Y". Gene 239 (1): 15–27. 1999. doi:10.1016/S0378-1119(99)00368-6. PMID 10571030. 
• "Evolutionary variation of the CCAAT-binding transcription factor NF-Y". Nucleic Acids Res. 20 (5): 1087–91. 1992. doi:10.1093/nar/20.5.1087. PMID 1549471. 
• "Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain". J. Biol. Chem. 267 (13): 8984–90. 1992. doi:10.1016/S0021-9258(19)50377-5. PMID 1577736. 
• "Repression of major histocompatibility complex I-A beta gene expression by dbpA and dbpB (mYB-1) proteins". Mol. Cell. Biol. 15 (9): 5092–9. 1995. doi:10.1128/mcb.15.9.5092. PMID 7651426. 
• "Human thymidine kinase CCAAT-binding protein is NF-Y, whose A subunit expression is serum-dependent in human IMR-90 diploid fibroblasts". J. Biol. Chem. 269 (27): 17893–8. 1994. doi:10.1016/S0021-9258(17)32393-1. PMID 8027044. 
• "Dominant negative analogs of NF-YA". J. Biol. Chem. 269 (32): 20340–6. 1994. doi:10.1016/S0021-9258(17)31997-X. PMID 8051128. 
• "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y". Mol. Cell. Biol. 17 (3): 1236–43. 1997. doi:10.1128/mcb.17.3.1236. PMID 9032250. 
• "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. 25 (11): 2174–81. 1997. doi:10.1093/nar/25.11.2174. PMID 9153318. 
• "Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y)". J. Biol. Chem. 272 (49): 30880–8. 1998. doi:10.1074/jbc.272.49.30880. PMID 9388234. 
• "NF-Y is associated with the histone acetyltransferases GCN5 and P/CAF". J. Biol. Chem. 273 (3): 1430–4. 1998. doi:10.1074/jbc.273.3.1430. PMID 9430679. 
• "Biochemical characterization of the NF-Y transcription factor complex during B lymphocyte development". J. Biol. Chem. 273 (29): 18220–9. 1998. doi:10.1074/jbc.273.29.18220. PMID 9660784. 
• "Purification and characterization of a protein binding to the SP6 kappa promoter. A potential role for CArG-box binding factor-A in kappa transcription". J. Biol. Chem. 273 (30): 18881–90. 1998. doi:10.1074/jbc.273.30.18881. PMID 9668064. 
• "The B subunit of the CAAT-binding factor NFY binds the central segment of the Co-activator p300". J. Biol. Chem. 274 (12): 7623–6. 1999. doi:10.1074/jbc.274.12.7623. PMID 10075648. 
• "CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation". Mol. Cell. Biol. 20 (20): 7716–25. 2000. doi:10.1128/MCB.20.20.7716-7725.2000. PMID 11003667. 
• "Functional interaction of NF-Y and Sp1 is required for type a natriuretic peptide receptor gene transcription". J. Biol. Chem. 276 (2): 1516–22. 2001. doi:10.1074/jbc.M006350200. PMID 11022037. 
• "Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor". J. Cell Sci. 114 (Pt 8): 1533–44. 2001. doi:10.1242/jcs.114.8.1533. PMID 11282029. 

External links

• NFYB+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook NF-YB

This article incorporates text from the United States National Library of Medicine, which is in the public domain.