Biology:SOX11
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene.[1][2][3]
Function
This intronless gene encodes a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis and adult neurogenesis.[3][4] Tuj1 and Tead2 are suggested as direct target of Sox11.[5][6][7]
Clinical aspect
Lymphocyte staining for SOX11 immunohistochemistry indicates mantle cell lymphoma (cyclin D1 positive and negative) rather than other mature lymphoid neoplasms or normal lymphocytes.[8]
Mutations in SOX11 are associated with Coffin–Siris syndrome[9] and mantle cell lymphoma.[10]
See also
- SOX genes
References
- ↑ "The human SOX11 gene: cloning, chromosomal assignment and tissue expression". Genomics 29 (2): 541–5. Sep 1995. doi:10.1006/geno.1995.9970. PMID 8666406.
- ↑ "Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity". The Journal of Biological Chemistry 278 (20): 17901–11. May 2003. doi:10.1074/jbc.M212211200. PMID 12637543.
- ↑ 3.0 3.1 "Entrez Gene: SOX11 SRY (sex determining region Y)-box 11". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6664.
- ↑ "Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis". The European Journal of Neuroscience 29 (11): 2103–14. Jun 2009. doi:10.1111/j.1460-9568.2009.06768.x. PMID 19490090.
- ↑ "The establishment of neuronal properties is controlled by Sox4 and Sox11". Genes & Development 20 (24): 3475–86. Dec 2006. doi:10.1101/gad.403406. PMID 17182872.
- ↑ "Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors". Nature Communications 1 (1): 9. Apr 2010. doi:10.1038/ncomms1008. PMID 20596238. Bibcode: 2010NatCo...1....9B.
- ↑ "Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells". Tissue Engineering. Part A 16 (11): 3385–94. Nov 2010. doi:10.1089/ten.tea.2010.0085. PMID 20626275.
- ↑ Anna Dusenbery, M.D., Mark R. Wick, M.D.. "Stains & CD markers - SOX11". https://www.pathologyoutlines.com/topic/stainssox11.html. Topic Completed: 1 January 2018. Minor changes: 12 August 2021
- ↑ "De novo SOX11 mutations cause Coffin-Siris syndrome". Nature Communications 5: 4011. 2014. doi:10.1038/ncomms5011. PMID 24886874. Bibcode: 2014NatCo...5.4011T.
- ↑ Vose, Julie M. (August 2017). "Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management". American Journal of Hematology 92 (8): 806–813. doi:10.1002/ajh.24797. ISSN 1096-8652. PMID 28699667.
Further reading
- "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Current Opinion in Genetics & Development 12 (4): 441–6. Aug 2002. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.
- "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Developmental Cell 3 (2): 167–70. Aug 2002. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
- "Partial cloning of SOX-11 and SOX-12, two new human SOX genes". Nucleic Acids Research 21 (12): 2943. Jun 1993. doi:10.1093/nar/21.12.2943. PMID 8332506.
- "Cooperative function of POU proteins and SOX proteins in glial cells". The Journal of Biological Chemistry 273 (26): 16050–7. Jun 1998. doi:10.1074/jbc.273.26.16050. PMID 9632656.
- "Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region". DNA Research 6 (5): 357–60. Oct 1999. doi:10.1093/dnares/6.5.357. PMID 10574465.
- "Differential expression of SOX4 and SOX11 in medulloblastoma". Journal of Neuro-Oncology 57 (3): 201–14. May 2002. doi:10.1023/A:1015773818302. PMID 12125983.
- "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics 3 (11): 1093–101. Nov 2004. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
- "Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells". Development 132 (13): 3045–54. Jul 2005. doi:10.1242/dev.01890. PMID 15944188.
- "NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY". The Journal of Biological Chemistry 280 (46): 38625–30. Nov 2005. doi:10.1074/jbc.M504127200. PMID 16166090.
- "Complex mosaicism in sex reversed SRY+ male twins". Cytogenetic and Genome Research 112 (1–2): 176–9. 2006. doi:10.1159/000087532. PMID 16276109.
External links
- Overview of all the structural information available in the PDB for UniProt: P35716 (Human Transcription factor SOX-11) at the PDBe-KB.
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