Biology:NKX2-2

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the NKX2-2 gene.[1][2][3]

Homeobox protein Nkx-2.2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.[3]

The expression of Nkx2-2 is regulated by an antisense RNA called Nkx2-2as.[4]

In the developing spinal cord, Nkx-2.2 regulates IRX3 thereby contributing to the proper differentiation of the ventral horn neurons.[5]

References

  1. "Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese". Diabetes 47 (8): 1356–1358. Aug 1998. doi:10.2337/diabetes.47.8.1356. PMID 9703340. 
  2. "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron 8 (2): 241–255. Feb 1992. doi:10.1016/0896-6273(92)90291-K. PMID 1346742. 
  3. 3.0 3.1 "Entrez Gene: NKX2-2 NK2 transcription factor related, locus 2 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4821. 
  4. "Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation". Biochemical and Biophysical Research Communications 372 (4): 691–696. Aug 2008. doi:10.1016/j.bbrc.2008.05.127. PMID 18538132. 
  5. "Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord". PLOS ONE 9 (11): e111430. November 2014. doi:10.1371/journal.pone.0111430. PMID 25398016. Bibcode2014PLoSO...9k1430L. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.