Biology:Neuropeptide Y receptor Y5
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Neuropeptide Y receptor type 5 is a protein that in humans is encoded by the NPY5R gene.[1][2][3]
Selective ligands
Agonists
- Neuropeptide Y (endogenous agonist, non subtype selective)
- BWX-46 (selective NPY5 agonist, CAS# 172997-92-1)
- Peptide YY
Antagonists
- CGP-71683 (CAS# 192322-50-2)
- FMS-586[4]
- L-152,804 (CAS# 6508-43-6)
- Lu AA-33810[5]
- MK-0557[6]
- NTNCB (CAS# 486453-65-0)[7]
- Velneperit (S-2367)
See also
References
- ↑ "A receptor subtype involved in neuropeptide-Y-induced food intake". Nature 382 (6587): 168–71. Jul 1996. doi:10.1038/382168a0. PMID 8700207.
- ↑ "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics 46 (2): 287–90. Dec 1997. doi:10.1006/geno.1997.5024. PMID 9417917.
- ↑ "Entrez Gene: NPY5R neuropeptide Y receptor Y5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4889.
- ↑ "Pharmacological characterization and feeding-suppressive property of FMS586 [3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin-4-yl-ethyl)-urea hydrochloride], a novel, selective, and orally active antagonist for neuropeptide Y Y5 receptor". The Journal of Pharmacology and Experimental Therapeutics 317 (2): 562–70. May 2006. doi:10.1124/jpet.105.099705. PMID 16436501.
- ↑ "The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity". The Journal of Pharmacology and Experimental Therapeutics 328 (3): 900–11. Mar 2009. doi:10.1124/jpet.108.144634. PMID 19098165.
- ↑ "NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs". Current Topics in Medicinal Chemistry 7 (17): 1721–33. 2007. doi:10.2174/156802607782341028. PMID 17979781. http://www.bentham-direct.org/pages/content.php?CTMC/2007/00000007/00000017/0009R.SGM. Retrieved 2020-04-16.
- ↑ "Discovery of potent and selective small molecule NPY Y5 receptor antagonists". Bioorganic & Medicinal Chemistry Letters 12 (13): 1767–9. Jul 2002. doi:10.1016/S0960-894X(02)00287-1. PMID 12067557.
Further reading
- "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology 440 (2–3): 173–87. Apr 2002. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.
- "Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior". The Journal of Biological Chemistry 271 (42): 26315–9. Oct 1996. doi:10.1074/jbc.271.42.26315. PMID 8824284.
- "Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation". Genomics 41 (3): 315–9. May 1997. doi:10.1006/geno.1997.4684. PMID 9169127.
- "Conservation of expression of neuropeptide Y5 receptor between human and rat hypothalamus and limbic regions suggests an integral role in central neuroendocrine control". The Journal of Neuroscience 19 (23): 10295–304. Dec 1999. doi:10.1523/JNEUROSCI.19-23-10295.1999. PMID 10575027.
- "Molecular identification of the long isoform of the human neuropeptide Y Y5 receptor and pharmacological comparison with the short Y5 receptor isoform". The Biochemical Journal 369 (Pt 3): 667–73. Feb 2003. doi:10.1042/BJ20020739. PMID 12398768.
- "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction". The Journal of Pharmacology and Experimental Therapeutics 306 (1): 147–56. Jul 2003. doi:10.1124/jpet.103.051227. PMID 12665544.
- "Functional characterization of human neuropeptide Y receptor subtype five specific antagonists using a luciferase reporter gene assay". Cellular Signalling 17 (4): 489–96. Apr 2005. doi:10.1016/j.cellsig.2004.09.006. PMID 15601626.
- "Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors". FASEB Journal 20 (11): 1924–6. Sep 2006. doi:10.1096/fj.05-4770fje. PMID 16891622.
- "Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans". Obesity 15 (4): 809–15. Apr 2007. doi:10.1038/oby.2007.610. PMID 17426313.
External links
- "Neuropeptide Y Receptors: Y5". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2372.
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