Biology:IL2RB

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Interleukin-2 receptor subunit beta is a protein that in humans is encoded by the IL2RB gene. Also known as CD122; IL15RB; P70-75.

Function

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit (also called CD25) and is not involved in signal transduction. The intermediate affinity form consists of a gamma/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.

This protein also forms one of the three subunits of the IL-15 receptor.

Activation of the receptor increases proliferation of CD8+ effector T cells.

Interactions

IL2RB has been shown to interact with:

• CISH,
• HGS,
• Janus kinase 1, and
• SHC1.

See also

• IL-2 receptor
• IL-15 receptor

Further reading

• "Alternate signalling pathways from the interleukin-2 receptor". Cytokine Growth Factor Rev. 13 (1): 27–40. 2002. doi:10.1016/S1359-6101(01)00023-5. PMID 11750878. 
• "Suppression of interleukin-2 and interleukin-2 receptor expression in Jurkat cells stably expressing the human immunodeficiency virus Tat protein". Cell. Immunol. 144 (1): 32–42. 1992. doi:10.1016/0008-8749(92)90223-C. PMID 1394441. 
• "Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line". Proc. Natl. Acad. Sci. U.S.A. 89 (7): 2674–8. 1992. doi:10.1073/pnas.89.7.2674. PMID 1557373. Bibcode: 1992PNAS...89.2674T. 
• "Interleukin-2 (IL-2) induces tyrosine kinase-dependent translocation of active raf-1 from the IL-2 receptor into the cytosol". J. Biol. Chem. 267 (22): 15281–4. 1992. doi:10.1016/S0021-9258(19)49530-6. PMID 1639773. 
• "The integrity of the conserved 'WS motif' common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction". EMBO J. 10 (11): 3191–7. 1991. doi:10.1002/j.1460-2075.1991.tb04881.x. PMID 1915291. 
• "The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment". Nucleic Acids Res. 18 (13): 3697–703. 1990. doi:10.1093/nar/18.13.3697. PMID 1973832. 
• "Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association". Science 252 (5012): 1523–8. 1991. doi:10.1126/science.2047859. PMID 2047859. Bibcode: 1991Sci...252.1523H. 
• "Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated". J. Biol. Chem. 265 (6): 3561–7. 1990. doi:10.1016/S0021-9258(19)39806-0. PMID 2303462. 
• "Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2379–83. 1990. doi:10.1073/pnas.87.6.2379. PMID 2315327. Bibcode: 1990PNAS...87.2379O. 
• "Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences". Proc. Natl. Acad. Sci. U.S.A. 87 (9): 3440–4. 1990. doi:10.1073/pnas.87.9.3440. PMID 2333293. Bibcode: 1990PNAS...87.3440G. 
• "Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies". Proc. Natl. Acad. Sci. U.S.A. 86 (6): 1982–6. 1989. doi:10.1073/pnas.86.6.1982. PMID 2467293. Bibcode: 1989PNAS...86.1982T. 
• "Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's". Science 244 (4904): 551–6. 1989. doi:10.1126/science.2785715. PMID 2785715. Bibcode: 1989Sci...244..551H. 
• "Lymphocyte activation by HIV-1 envelope glycoprotein". Nature 335 (6189): 445–8. 1988. doi:10.1038/335445a0. PMID 2843775. Bibcode: 1988Natur.335..445K. https://zenodo.org/record/1233075. 
• "Localization of the gene encoding the human interleukin-2 receptor on chromosome 10". Science 228 (4707): 1547–9. 1985. doi:10.1126/science.3925551. PMID 3925551. Bibcode: 1985Sci...228.1547L. 
• "The interleukin-2 and interleukin-4 receptors studied by molecular modelling". Structure 2 (9): 839–51. 1994. doi:10.1016/S0969-2126(94)00085-9. PMID 7529123. 
• "Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway". Immunity 2 (1): 89–100. 1995. doi:10.1016/1074-7613(95)90081-0. PMID 7600304. 
• "Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor". EMBO J. 14 (15): 3654–63. 1995. doi:10.1002/j.1460-2075.1995.tb00035.x. PMID 7641685. 
• "Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit". J. Biol. Chem. 268 (30): 22765–70. 1993. doi:10.1016/S0021-9258(18)41592-X. PMID 7693677. 
• "Constitutive expression of human immunodeficiency virus type 1 tat gene inhibits interleukin 2 and interleukin 2 receptor expression in a human CD4+ T lymphoid (H9) cell line". AIDS Res. Hum. Retroviruses 11 (1): 31–40. 1995. doi:10.1089/aid.1995.11.31. PMID 7734194. 
• "Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation". Cell 81 (2): 223–31. 1995. doi:10.1016/0092-8674(95)90332-1. PMID 7736574. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.