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Short description : Chemical compound
Isopropamide Clinical data MedlinePlus a694006 Routes of administration Oral ATC code Legal status Legal status
US : ℞-only and Unscheduled
In general: unscheduled
Identifiers
4-amino-N,N -diisopropyl-N -methyl-4-oxo-3,3-diphenylbutan-1-aminium
CAS Number PubChem CID DrugBank ChemSpider UNII ChEMBL Chemical and physical data Formula C 23 H 33 N 2 O + Molar mass 353.530 g·mol−1 3D model (JSmol )
O=C(N)C(c1ccccc1)(c2ccccc2)CC[N+](C(C)C)(C(C)C)C
InChI=1S/C23H32N2O/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26)/p+1
Y Key:JTPUMZTWMWIVPA-UHFFFAOYSA-O
Y
N Y (what is this?) (verify)
Isopropamide (R79 ) is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders involving hyperacidity (gastrointestinal acidosis) and hypermotility. Chemically, it contains a quaternary ammonium group. It is most often provided as an iodide salt, but is also available as a bromide or chloride salt. It was discovered at Janssen Pharmaceutica in 1954.
References
Further reading
"Isopropamide iodide: a long-acting anticholinergic". Delaware Medical Journal 29 (10): 265–9. October 1957. PMID 13473394 .
"Effect of isopropamide iodide on basal gastric secretion in the human". Gastroenterology 33 (5): 730–6. November 1957. doi :10.1016/S0016-5085(19)35625-2 . PMID 13480414 .
mAChRs
Agonists Antagonists
3-Quinuclidinyl benzilate
4-DAMP
Aclidinium bromide (+formoterol )
Abediterol
AF-DX 250
AF-DX 384
Ambutonium bromide
Anisodamine
Anisodine
Antihistamines (first-generation) (e.g., brompheniramine , buclizine , captodiame , chlorphenamine (chlorpheniramine) , cinnarizine , clemastine , cyproheptadine , dimenhydrinate , [[Chemistry:Dimetdimetindene, Diphenhydramine |diphenhydramine]], doxylamine , meclizine , mepyramine (pyrilamine) , mequitazine , perlapine , phenindamine , pheniramine , Phenyltoloxamine|Phenyltoloxamine ]]]], promethazine , propiomazine , triprolidine )
AQ-RA 741
Atropine
Atropine methonitrate
Atypical antipsychotics (e.g., clozapine, Chemistry :Fluperlapine
Precursors (and prodrugs)
Original source: https://en.wikipedia.org/wiki/Isopropamide. Read more