Chemistry:1-(2-Chloro-N-methylbenzimidoyl)cyclopentanol

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Short description: Chemical compound


1-(2-Chloro-N-methylbenzimidoyl)cyclopentanol
Hydroxyketimine structure.png
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC13H16ClNO
Molar mass237.73 g·mol−1
3D model (JSmol)

1-(2-Chloro-N-methylbenzimidoyl)cyclopentanol, sometimes misleadingly referred to as hydroxylimine hydrochloride, is a chemical compound which is the final intermediate in the synthesis of ketamine, an anaesthetic drug which is also subject to recreational abuse. This chemical intermediate is not active as a drug in its own right, and is legal in most countries, but is readily converted into ketamine by dissolving it in a suitable high-boiling point solvent and heating, with no other chemicals required.[1][2] This has made it subject to illicit trade as a drug precursor, and it has sometimes been seized by law enforcement agencies in significant quantities, leading to it being specifically banned as a controlled drug precursor in some jurisdictions such as Taiwan.[3][4]

See also

References

  1. Stevens CL, "Aminoketones and methods for their production", US patent 3254124, issued 1966-05-31, assigned to Parke Davis & Co.
  2. "Syntheses of Ketamine and Related Analogues: A Mini Review.". Synthesis 50 (21): 4201–4215. 2018. doi:10.1055/s-0037-1609935. 
  3. "200 kg of ketamine precursor seized at Taoyuan Airport". Taiwan News. 1 January 2009. https://www.taiwannews.com.tw/en/news/827352. 
  4. "Taiwan catches 2 tons of drugs hidden inside machinery from China.". Taiwan News. 31 March 2018. https://www.taiwannews.com.tw/en/news/3395120.