Biology:Sulfotransferase

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Short description: Class of enzymes which transfer a sulfo group (–SO3) between molecules
Sulfotransferase
Sulfotransferase SULT1A3.png
Crystal Structure of Human Sulfotransferase SULT1A3 in Complex with Dopamine and 3-Phosphoadenosine 5-Phosphate
Identifiers
EC number2.8.2.-
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

In biochemistry, sulfotransferases (SULTs) are transferase enzymes that catalyze the transfer of a sulfo group (R–SO
3
) from a donor molecule to an acceptor alcohol (R–OH) or amine (R–NH
2
).[1] The most common sulfo group donor is 3'-phosphoadenosine-5'-phosphosulfate (PAPS). In the case of alcohol as acceptor, the product is a sulfate (R–OSO
3
):

[math]\displaystyle{ \ce{R-SO3-} \ + \ \ce{R'-OH} \quad \xrightarrow[\text{ SULT }]{} \quad \ce{R-H} \ + \ \ce{R'-OSO3-} }[/math]

whereas an amine leads to a sulfamate (R–NH–SO
3
):

[math]\displaystyle{ \ce{R-SO3-} \ + \ \ce{R'-NH2} \quad \xrightarrow[\text{ SULT }]{} \quad \ce{R-H} \ + \ \ce{R'-NHSO3-} }[/math]

Both reactive groups for a sulfonation via sulfotransferases may be part of a protein, lipid, carbohydrate or steroid.[2]

General structure of a sulfonic acid with the blue marked functional group

Examples

The following are examples of sulfotransferases:

See also

References

  1. Negishi M; Pedersen LG; Petrotchenko E et al. (2001). "Structure and function of sulfotransferases". Arch. Biochem. Biophys. 390 (2): 149–57. doi:10.1006/abbi.2001.2368. PMID 11396917. https://zenodo.org/record/1229406. 
  2. "Sulfotransferase structural biology and inhibitor discovery". Drug Discov. Today 9 (23): 1003–11. 2004. doi:10.1016/S1359-6446(04)03273-8. PMID 15574316. 

External links