Biology:PRKACG
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
cAMP-dependent protein kinase catalytic subunit gamma is an enzyme that in humans is encoded by the PRKACG gene.[1][2][3]
Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit.[3]
Interactions
PRKACG has been shown to interact with Ryanodine receptor 2.[4]
References
- ↑ "Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase". Mol Endocrinol 4 (3): 465–75. June 1990. doi:10.1210/mend-4-3-465. PMID 2342480.
- ↑ "The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon". Genomics 49 (2): 290–7. August 1998. doi:10.1006/geno.1998.5240. PMID 9598317.
- ↑ 3.0 3.1 "Entrez Gene: PRKACG protein kinase, cAMP-dependent, catalytic, gamma". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5568.
- ↑ Marx, S O; Reiken S; Hisamatsu Y; Jayaraman T; Burkhoff D; Rosemblit N; Marks A R (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell (UNITED STATES) 101 (4): 365–76. doi:10.1016/S0092-8674(00)80847-8. ISSN 0092-8674. PMID 10830164.
Further reading
- Foss KB; Simard J; Bérubé D; Beebe, S.J.; Sandberg, M.; Grzeschik, K.-H.; Gagné, R.; Hansson, V. et al. (1992). "Localization of the catalytic subunit C gamma of the cAMP-dependent protein kinase gene (PRKACG) to human chromosome region 9q13". Cytogenet. Cell Genet. 60 (1): 22–5. doi:10.1159/000133286. PMID 1339328.
- Hofmann B; Nishanian P; Baldwin RL; Insixiengmay, P; Nel, A; Fahey, JL (1991). "HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism". J. Immunol. 145 (11): 3699–705. doi:10.4049/jimmunol.145.11.3699. PMID 1978848.
- Hofmann B; Nishanian P; Nguyen T; Insixiengmay, P; Fahey, JL (1993). "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6676–80. doi:10.1073/pnas.90.14.6676. PMID 7688126. Bibcode: 1993PNAS...90.6676H.
- Hofmann B; Nishanian P; Fan J; Nguyen, T.; Fahey, J. L. (1994). "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro". AIDS 8 (7): 1016–7. doi:10.1097/00002030-199407000-00025. PMID 7946090.
- Swingler S; Gallay P; Camaur D; Song, J; Abo, A; Trono, D (1997). "The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix". J. Virol. 71 (6): 4372–7. doi:10.1128/JVI.71.6.4372-4377.1997. PMID 9151826.
- "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. 1997. doi:10.1074/jbc.272.36.22385. PMID 9278385.
- Liapi C; Takahashi N; Raynaud F; Evain-Brion, Daniele; Anderson, Wayne B. (1998). "Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts". J. Invest. Dermatol. 110 (4): 332–7. doi:10.1046/j.1523-1747.1998.00149.x. PMID 9540970.
- Zidovetzki R; Wang JL; Chen P; Jeyaseelan, Raju; Hofman, Florence (1998). "Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways". AIDS Res. Hum. Retroviruses 14 (10): 825–33. doi:10.1089/aid.1998.14.825. PMID 9671211.
- Mayne M; Bratanich AC; Chen P; Rana, Farazana; Nath, Avindra; Power, Christopher (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation 5 (3–4): 184–92. doi:10.1159/000026336. PMID 9730685.
- Bodnar RJ; Xi X; Li Z; Berndt, MC; Du, X (2003). "Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta)". J. Biol. Chem. 277 (49): 47080–7. doi:10.1074/jbc.M208329200. PMID 12361948.
- Strausberg RL; Feingold EA; Grouse LH; Derge, JG; Klausner, RD; Collins, FS; Wagner, L; Shenmen, CM et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Cartier C; Hemonnot B; Gay B; Bardy, M; Sanchiz, C; Devaux, C; Briant, L (2003). "Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein". J. Biol. Chem. 278 (37): 35211–9. doi:10.1074/jbc.M301257200. PMID 12842892.
- Masci AM; Galgani M; Cassano S; De Simone, S; Gallo, A; De Rosa, V; Zappacosta, S; Racioppi, L (2004). "HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling". J. Leukoc. Biol. 74 (6): 1117–24. doi:10.1189/jlb.0503239. PMID 12972513.
- "Characterization of the cAMP-dependent protein kinase catalytic subunit Cgamma expressed and purified from sf9 cells". Protein Expr. Purif. 35 (1): 156–69. 2004. doi:10.1016/j.pep.2004.01.006. PMID 15039079.
- Stevanin G; Hahn V; Lohmann E; Bouslam, N; Gouttard, M; Soumphonphakdy, C; Welter, ML; Ollagnon-Roman, E et al. (2004). "Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14". Arch. Neurol. 61 (8): 1242–8. doi:10.1001/archneur.61.8.1242. PMID 15313841.
- Gerhard DS; Wagner L; Feingold EA; Shenmen, CM; Grouse, LH; Schuler, G; Klein, SL; Old, S et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
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