Biology:Neurogenin-2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Neurogenin-2 is a protein that in humans is encoded by the NEUROG2 gene.[1]
Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis.[2]
It has been found to reprogram astrocytes to glutamergic neurons when expressed.[3]
References
- ↑ "Entrez Gene: neurogenin 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=63973.
- ↑ "Neurogenin 2 controls cortical neuron migration through regulation of Rnd2". Nature 455 (7209): 114–8. September 2008. doi:10.1038/nature07198. PMID 18690213. Bibcode: 2008Natur.455..114H.
- ↑ Liu, Fei; Zhang, Yijie; Chen, Fuliang; Yuan, Jiacheng; Li, Sanlan; Han, Sue; Lu, Dengyu; Geng, Junlan et al. (2021-03-01). "Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord" (in en). Cell Death & Disease 12 (3): 225. doi:10.1038/s41419-021-03498-x. ISSN 2041-4889. PMID 33649354.
Further reading
- "Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors.". Dev. Biol. 180 (1): 227–41. 1996. doi:10.1006/dbio.1996.0297. PMID 8948587.
- "Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers.". Dev. Biol. 229 (2): 327–39. 2001. doi:10.1006/dbio.2000.9984. PMID 11203697.
- "Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells.". Stem Cells Dev. 16 (4): 667–81. 2007. doi:10.1089/scd.2006.0115. PMID 17784840.
- "Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease.". Neurosci. Lett. 468 (3): 195–197. 2009. doi:10.1016/j.neulet.2009.10.078. PMID 19879328.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro". FEBS Lett. 582 (5): 537–42. 2008. doi:10.1016/j.febslet.2008.01.018. PMID 18242186.
- "The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons". Neuron 20 (3): 483–94. 1998. doi:10.1016/S0896-6273(00)80989-7. PMID 9539123.
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