Biology:PAX4

Short description: Protein-coding gene in humans

Generic protein structure example

Paired box gene 4, also known as PAX4, is a protein which in humans is encoded by the PAX4 gene.

Function

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box gene 4 is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.

See also

• Pax genes
• Maturity onset diabetes of the young type 9

Further reading

• "Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes". Developmental Cell 26 (1): 86–100. Jul 2013. doi:10.1016/j.devcel.2013.05.018. PMID 23810513. 
• "The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells". Cell 138 (3): 449–62. Aug 2009. doi:10.1016/j.cell.2009.05.035. PMID 19665969. 
• "The gene Pax4 is an essential regulator of pancreatic beta-cell development". Molecules and Cells 18 (3): 289–94. Dec 2004. PMID 15650323. 
• "Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9". Nature Genetics 3 (4): 292–8. Apr 1993. doi:10.1038/ng0493-292. PMID 7981748. 
• "Assignment of the human PAX4 gene to chromosome band 7q32 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics 66 (2): 132–4. 1994. doi:10.1159/000133684. PMID 8287686. 
• "Mapping of the human homologs of the murine paired-box-containing genes". Mammalian Genome 4 (2): 78–82. 1993. doi:10.1007/BF00290430. PMID 8431641. 
• "Molecular cloning of mouse paired-box-containing gene (Pax)-4 from an islet beta cell line and deduced sequence of human Pax-4". Biochemical and Biophysical Research Communications 242 (1): 176–80. Jan 1998. doi:10.1006/bbrc.1997.7935. PMID 9439631. 
• "Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue". Biochemical and Biophysical Research Communications 243 (2): 628–33. Feb 1998. doi:10.1006/bbrc.1998.8144. PMID 9480859. 
• "Organisation of the human PAX4 gene and its exclusion as a candidate for the Wolcott-Rallison syndrome". Journal of Medical Genetics 35 (4): 288–92. Apr 1998. doi:10.1136/jmg.35.4.288. PMID 9598721. 
• "Isolation and characterization of the human PAX4 gene". Diabetes 47 (10): 1650–3. Oct 1998. doi:10.2337/diabetes.47.10.1650. PMID 9753306. 
• "Autoregulation and maturity onset diabetes of the young transcription factors control the human PAX4 promoter". The Journal of Biological Chemistry 275 (47): 36910–9. Nov 2000. doi:10.1074/jbc.M005202200. PMID 10967107. 
• "Expression of dominant negative form of PAX4 in human insulinoma". Biochemical and Biophysical Research Communications 282 (1): 34–40. Mar 2001. doi:10.1006/bbrc.2001.4552. PMID 11263967. 
• "A missense mutation of Pax4 gene (R121W) is associated with type 2 diabetes in Japanese". Diabetes 50 (12): 2864–9. Dec 2001. doi:10.2337/diabetes.50.12.2864. PMID 11723072. 
• "Beta-cell dysfunction in late-onset diabetic subjects carrying homozygous mutation in transcription factors NeuroD1 and Pax4". Metabolism 51 (9): 1161–5. Sep 2002. doi:10.1053/meta.2002.34707. PMID 12200761. 
• "PAX4 mutation (R121W) as a prodiabetic variant in Okinawans". Biochemical and Biophysical Research Communications 302 (2): 342–4. Mar 2003. doi:10.1016/S0006-291X(03)00176-1. PMID 12604352. 
• "Regulation of Pax4 paired homeodomain gene by neuron-restrictive silencer factor". The Journal of Biological Chemistry 278 (37): 35057–62. Sep 2003. doi:10.1074/jbc.M305891200. PMID 12829700. 
• "Interaction and association analysis of a type 1 diabetes susceptibility locus on chromosome 5q11-q13 and the 7q32 chromosomal region in Scandinavian families". Diabetes 53 (6): 1584–91. Jun 2004. doi:10.2337/diabetes.53.6.1584. PMID 15161765. 
• "The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets". The Journal of Cell Biology 167 (6): 1123–35. Dec 2004. doi:10.1083/jcb.200405148. PMID 15596543. 

External links

• PAX4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.