Biology:Lysine 6-dehydrogenase
From HandWiki
| Lysine 6-dehydrogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.4.1.18 | ||||||||
| CAS number | 89400-30-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Lysine 6-dehydrogenase (EC 1.4.1.18, L-lysine epsilon-dehydrogenase, L-lysine 6-dehydrogenase, LysDH) is an enzyme with systematic name L-lysine:NAD+ 6-oxidoreductase (deaminating).[1][2][3][4] This enzyme catalyses the following chemical reaction
- L-lysine + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NADH + H+ + NH3 (overall reaction)
- (1a) L-lysine + NAD+ + H2O [math]\displaystyle{ \rightleftharpoons }[/math] (S)-2-amino-6-oxohexanoate + NADH + H+ + NH3
- (1b) (S)-2-amino-6-oxohexanoate [math]\displaystyle{ \rightleftharpoons }[/math] (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O (spontaneous)
The enzyme is highly specific for L-lysine as substrate, although S-(2-aminoethyl)-L-cysteine can act as a substrate, but more slowly.
References
- ↑ "Occurrence of L-lysine epsilon-dehydrogenase in Agrobacterium tumefaciens". Journal of Bacteriology 150 (1): 398–401. April 1982. doi:10.1128/jb.150.1.398-401.1982. PMID 6801024.
- ↑ "Purification and properties of L-lysine ε-dehydrogenase from Agrobacterium tumefaciens". Agric. Biol. Chem. 49 (7): 2253–2255. 1985. doi:10.1271/bbb1961.49.2253.
- ↑ "Properties of L-lysine epsilon-dehydrogenase from Agrobacterium tumefaciens". Journal of Biochemistry 105 (6): 1002–8. June 1989. doi:10.1093/oxfordjournals.jbchem.a122757. PMID 2768207.
- ↑ "Highly stable L-lysine 6-dehydrogenase from the thermophile Geobacillus stearothermophilus isolated from a Japanese hot spring: characterization, gene cloning and sequencing, and expression". Applied and Environmental Microbiology 70 (2): 937–42. February 2004. doi:10.1128/aem.70.2.937-942.2004. PMID 14766574. Bibcode: 2004ApEnM..70..937H.
External links
- Lysine+6-dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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