Biology:KIF4A
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Kinesin family member 4A is a protein that in humans is encoded by the KIF4A gene.[1][2]
Function
Kinesins, such as KIF4A, are microtubule-based motor proteins that generate directional movement along microtubules. They are involved in many crucial cellular processes, including cell division.[2]
Interactions
KIF4A has been shown to interact with HMG20B[3] and DNMT3B.[4]
Clinical significance
NTCP is the entry receptor for both Hepatitis B (HBV) and Hepatitis D viruses (HDV).[5] KIF4 was found to play an essential role in HBV and HDV infection through its regulation of the retrograde transport of NTCP from the cytoplasm to the cell surface where it acts as a receptor for HBV/HDV infection.[6]
References
- ↑ "Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization". Cytogenetics and Cell Genetics 88 (1–2): 41–42. Jun 2000. doi:10.1159/000015482. PMID 10773663.
- ↑ 2.0 2.1 "Entrez Gene: KIF4A kinesin family member 4A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=24137.
- ↑ "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal 374 (Pt 2): 497–503. September 2003. doi:10.1042/BJ20030452. PMID 12809554.
- ↑ "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research 32 (9): 2716–2729. 2004. doi:10.1093/nar/gkh589. PMID 15148359.
- ↑ Chen, Zhijian J, ed (November 2012). "Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus". eLife 1: e00049. doi:10.7554/eLife.00049. PMID 23150796.
- ↑ "The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro". PLOS Pathogens 18 (3): e1009983. March 2022. doi:10.1371/journal.ppat.1009983. PMID 35312737.
Further reading
- "A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally". The Journal of Cell Biology 127 (1): 187–201. October 1994. doi:10.1083/jcb.127.1.187. PMID 7929562.
- "Increased chromokinesin immunoreactivity in retinoblastoma cells". Gene 189 (2): 263–267. April 1997. doi:10.1016/S0378-1119(96)00860-8. PMID 9168136.
- "Cellular motor protein KIF-4 associates with retroviral Gag". Journal of Virology 73 (12): 10508–10513. December 1999. doi:10.1128/JVI.73.12.10508-10513.1999. PMID 10559369.
- "Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1493 (1–2): 219–224. September 2000. doi:10.1016/s0167-4781(00)00151-2. PMID 10978527.
- "Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis". The Biochemical Journal 360 (Pt 3): 549–556. December 2001. doi:10.1042/0264-6021:3600549. PMID 11736643.
- "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal 374 (Pt 2): 497–503. September 2003. doi:10.1042/BJ20030452. PMID 12809554.
- "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications 308 (4): 793–801. September 2003. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
- "Kinesin superfamily protein member 4 (KIF4) is localized to midzone and midbody in dividing cells". Experimental & Molecular Medicine 36 (1): 93–97. February 2004. doi:10.1038/emm.2004.13. PMID 15031677.
- "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research 32 (9): 2716–2729. 2004. doi:10.1093/nar/gkh589. PMID 15148359.
- "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation". The EMBO Journal 23 (16): 3237–3248. August 2004. doi:10.1038/sj.emboj.7600347. PMID 15297875.
- "Human chromokinesin KIF4A functions in chromosome condensation and segregation". The Journal of Cell Biology 166 (5): 613–620. August 2004. doi:10.1083/jcb.200401142. PMID 15326200.
- "Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis". Proceedings of the National Academy of Sciences of the United States of America 102 (2): 343–348. January 2005. doi:10.1073/pnas.0408438102. PMID 15625105. Bibcode: 2005PNAS..102..343Z.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. January 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America 103 (14): 5391–5396. April 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N.
- "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology 24 (10): 1285–1292. October 2006. doi:10.1038/nbt1240. PMID 16964243.
External links
 |  |
