Biology:Fibrolase

From HandWiki
Fibrolase
Identifiers
EC number3.4.24.72
CAS number116036-70-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Fibrolase (EC 3.4.24.72, fibrinolytic proteinase, Agkistrodon contortrix contortrix metalloproteinase, Agkistrodon contortrix contortrix venom metalloproteinase) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Hydrolysis of -Ala14-Leu- in insulin B chain and -Lys413-Leu- in alpha-chain of fibrinogen

This enzyme is present in the venom of the southern copperhead snake (Agkistrodon contortrix contortrix).

References

  1. "A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems". Thrombosis Research 52 (6): 541–52. December 1988. doi:10.1016/0049-3848(88)90127-2. PMID 3232124. 
  2. "Purification and characterization of a fibrinolytic enzyme from venom of the southern copperhead snake (Agkistrodon contortrix contortrix)". Archives of Biochemistry and Biophysics 289 (2): 197–207. September 1991. doi:10.1016/0003-9861(91)90462-r. PMID 1898066. 
  3. "Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix contortrix venom". Protein Science 1 (5): 590–600. May 1992. doi:10.1002/pro.5560010505. PMID 1304358. 
  4. "Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities". Journal of Chromatography B 662 (2): 227–43. December 1994. doi:10.1016/0378-4347(94)00202-9. PMID 7719479. 
  5. "Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basiliscus basiliscus: cleavage site specificity towards the alpha-chain of fibrin". Thrombosis Research 74 (4): 355–67. May 1994. doi:10.1016/0049-3848(94)90151-1. PMID 8085237. 

External links