Biology:ADAM19

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

ADAM19 (A Disintegrin And Metalloproteinase 19, MADDAM, meltrin beta), is a human gene.[1]

Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Alternative splicing results in two transcript variants.[1]

Interactions

ADAM19 has been shown to interact with ABI2.[2]

References

  1. 1.0 1.1 "Entrez Gene: ADAM19 ADAM metallopeptidase domain 19 (meltrin beta)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8728. 
  2. "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Molecular Biology Reports 29 (3): 317–23. Sep 2002. doi:10.1023/A:1020409217215. PMID 12463424. 

External links

Further reading