Biology:Excitatory amino acid transporter 4

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Short description: Protein found in humans


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene.[1][2]

EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions.[2]

References

  1. "Entrez Gene: solute carrier family 1 (high affinity aspartate/glutamate transporter)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6511. 
  2. 2.0 2.1 "An excitatory amino-acid transporter with properties of a ligand-gated chloride channel". Nature 375 (6532): 599–603. June 1995. doi:10.1038/375599a0. PMID 7791878. 

Further reading