Biology:Vesicular glutamate transporter 1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.[1][2][3]
The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.[3]
See also
References
- ↑ "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter". J Neurochem 66 (6): 2227–38. Jul 1996. doi:10.1046/j.1471-4159.1996.66062227.x. PMID 8632143.
- ↑ "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter". J Neurochem 74 (6): 2622–5. Jun 2000. doi:10.1046/j.1471-4159.2000.0742622.x. PMID 10820226.
- ↑ 3.0 3.1 "Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57030.
Further reading
- "Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter.". Science 289 (5481): 957–60. 2000. doi:10.1126/science.289.5481.957. PMID 10938000. Bibcode: 2000Sci...289..957B.
- "Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons.". Nature 407 (6801): 189–94. 2000. doi:10.1038/35025070. PMID 11001057. Bibcode: 2000Natur.407..189T.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons.". Schizophrenia Research 73 (2–3): 159–72. 2005. doi:10.1016/j.schres.2004.05.010. PMID 15653259.
- "Vesicular glutamate transporter 1 immunostaining in the normal and epileptic human cerebral cortex.". Neuroscience 134 (1): 59–68. 2005. doi:10.1016/j.neuroscience.2005.03.038. PMID 15961236. https://zenodo.org/record/896283.
- "Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis.". J. Neurochem. 97 (4): 1111–25. 2006. doi:10.1111/j.1471-4159.2006.03821.x. PMID 16606361.
- "Docking and homology modeling explain inhibition of the human vesicular glutamate transporters.". Protein Sci. 16 (9): 1819–29. 2007. doi:10.1110/ps.072944707. PMID 17660252.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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