Biology:Deoxyadenosine kinase

From HandWiki
deoxyadenosine kinase
Identifiers
EC number2.7.1.76
CAS number37278-12-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a deoxyadenosine kinase (EC 2.7.1.76) is an enzyme that catalyzes the chemical reaction

ATP + deoxyadenosine [math]\displaystyle{ \rightleftharpoons }[/math] ADP + dAMP

Thus, the two substrates of this enzyme are ATP and deoxyadenosine, whereas its two products are ADP and dAMP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:deoxyadenosine 5'-phosphotransferase. This enzyme is also called purine-deoxyribonucleoside kinase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JAQ.

References

  • "Purification and some properties of a deoxyribonucleoside kinase from L1210 cells". Cancer Res. 42 (8): 3033–9. 1982. PMID 6284353. 
  • "The regulatory properties of deoxyadenosine kinase". Biochim. Biophys. Acta 161 (2): 578–80. 1968. doi:10.1016/0005-2787(68)90139-1. PMID 5667299.