Biology:Coccolysin

Short description: Enzyme

Coccolysin (EC 3.4.24.30, Streptococcus thermophilus intracellular proteinase, EM 19000) is an enzyme.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

Preferential cleavage: -Leu, -Phe, -Tyr, -Ala

This endopeptidase is present in S. thermophilus, S. diacetilactis and S. faecalis.

References

↑ "[General properties and specificity of action of a neutral intracellular endopeptidase from Streptococcus thermophilus]". Biochimie 56 (9): 1173–1181. 1974. doi:10.1016/s0300-9084(74)80008-8. PMID 4451671.
↑ "General properties and substrate specificity of an intracellular neutral protease from Streptococcus diaceti lactis". Annales de Biologie Animale, Biochimie, et Biophysique 16 (6): 851–868. 1976. doi:10.1051/rnd:19760608. https://hal.archives-ouvertes.fr/hal-00897137/file/hal-00897137.pdf.
↑ "The purification and properties of a fibrinolytic neutral metalloendopeptidase from Streptococcus faecalis". Archives of Biochemistry and Biophysics 202 (2): 629–638. July 1980. doi:10.1016/0003-9861(80)90471-3. PMID 6779709.
↑ "Purification and substrate specificity of a strongly hydrophobic extracellular metalloendopeptidase ("gelatinase") from Streptococcus faecalis (strain 0G1-10)". The Journal of Biological Chemistry 264 (6): 3325–3334. February 1989. doi:10.1016/S0021-9258(18)94069-X. PMID 2536744.

Coccolysin at the US National Library of Medicine Medical Subject Headings (MeSH)

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v t e Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)