Biology:CACNA1B
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
The voltage-dependent N-type calcium channel subunit alpha-1B is a protein that in humans is encoded by the CACNA1B gene.[1][2][3] The α1B protein, together with β and α2δ subunits forms N-type calcium channel (Cav2.2 channel) PMID 26386135. It is a R-type calcium channel.
References
- ↑ "Entrez Gene: CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=774.
- ↑ "Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits". Genomics 30 (3): 605–9. Dec 1995. doi:10.1006/geno.1995.1284. PMID 8825650.
- ↑ "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacological Reviews 57 (4): 411–25. Dec 2005. doi:10.1124/pr.57.4.5. PMID 16382099.
Further reading
- "The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels". The Journal of Biological Chemistry 279 (33): 34705–14. Aug 2004. doi:10.1074/jbc.M310848200. PMID 15166237.
- "A direct repeat of N-type Ca2+ channel alpha1B gene functions as a negative regulatory element in HeLa cells". Molecules and Cells 13 (2): 341–6. Apr 2002. doi:10.1016/S1016-8478(23)15043-6. PMID 12018859.
- "Mechanosensitivity of N-type calcium channel currents". Biophysical Journal 83 (5): 2560–74. Nov 2002. doi:10.1016/S0006-3495(02)75267-3. PMID 12414690. Bibcode: 2002BpJ....83.2560C.
- "Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk". Molecular Psychiatry 14 (3): 252–60. Mar 2009. doi:10.1038/mp.2008.133. PMID 19065143.
- "Alternative splicing in the C-terminus of CaV2.2 controls expression and gating of N-type calcium channels". The Journal of Physiology 576 (Pt 1): 119–34. Oct 2006. doi:10.1113/jphysiol.2006.115030. PMID 16857708.
- "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacological Reviews 57 (4): 411–25. Dec 2005. doi:10.1124/pr.57.4.5. PMID 16382099.
- "Mechanism of SNARE protein binding and regulation of Cav2 channels by phosphorylation of the synaptic protein interaction site". Molecular and Cellular Neurosciences 28 (1): 1–17. Jan 2005. doi:10.1016/j.mcn.2004.08.019. PMID 15607937.
- "A PKC epsilon-ENH-channel complex specifically modulates N-type Ca2+ channels". Nature Neuroscience 6 (5): 468–75. May 2003. doi:10.1038/nn1041. PMID 12665800.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. Nov 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C". The Journal of Neuroscience 25 (8): 1914–23. Feb 2005. doi:10.1523/JNEUROSCI.4790-04.2005. PMID 15728831.
- "The importance of occupancy rather than affinity of CaV(beta) subunits for the calcium channel I-II linker in relation to calcium channel function". The Journal of Physiology 574 (Pt 2): 387–98. Jul 2006. doi:10.1113/jphysiol.2006.109744. PMID 16627564.
- "Several structural domains contribute to the regulation of N-type calcium channel inactivation by the beta 3 subunit". The Journal of Biological Chemistry 279 (5): 3793–800. Jan 2004. doi:10.1074/jbc.M308991200. PMID 14602720.
- "Synaptic targeting of N-type calcium channels in hippocampal neurons". The Journal of Neuroscience 22 (16): 6939–52. Aug 2002. doi:10.1523/JNEUROSCI.22-16-06939.2002. PMID 12177192.
- "Characteristics of block by Pb2+ of function of human neuronal L-, N-, and R-type Ca2+ channels transiently expressed in human embryonic kidney 293 cells". Molecular Pharmacology 62 (6): 1418–30. Dec 2002. doi:10.1124/mol.62.6.1418. PMID 12435810.
- "Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels". The Journal of Biological Chemistry 277 (43): 40342–51. Oct 2002. doi:10.1074/jbc.M203425200. PMID 12161429.
- Schwartz, Arnold, ed (2008). "Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity". PLOS ONE 3 (10): e3560. doi:10.1371/journal.pone.0003560. PMID 18958281. Bibcode: 2008PLoSO...3.3560V.
- "Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin". The Journal of Biological Chemistry 276 (35): 32756–62. Aug 2001. doi:10.1074/jbc.M100929200. PMID 11438518.
- "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science 302 (5653): 2141–4. Dec 2003. doi:10.1126/science.1090100. PMID 14684825. Bibcode: 2003Sci...302.2141J.
- "G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels". Neuron 46 (6): 891–904. Jun 2005. doi:10.1016/j.neuron.2005.05.011. PMID 15953418.
External links
- CACNA1B+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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