Organization:The AIM center
The Autophagy, Inflammation and Metabolism (AIM) center[1][2] is an NIH-funded[3] Center of Biomedical Research Excellence focused on the study of autophagy as a fundamental biological process and how it intersects with metabolism and quality control processes in eukaryotic cells. A special emphasis is on the role or autophagy in a wide spectrum of diseases with metabolic, inflammatory and immunological aspects. At the fundamental level, autophagy is a cytoplasmic pathway for the disposal of damaged or surplus organelles such as mitochondria, peroxisomes, lysosomes, endoplasmic reticulum, ribosomes, protein aggregates and also serves as a catabolic process providing nutrients through autodigestion at times of starvation. Autophagy has been implicated in cancer, neurodegeneration such as Alzheimer's disease, Huntington's disease and Parkinson's disease, diabetes, development, infections and immune diseases, as well as a process of relevance for aging.
The purpose of the AIM center is to promote autophagy research at the international, national and regional levels and to provide resources to communities of scholars interested in this process in any context including basic science or translational research. AIM has scientific cores providing technical resources for study of autophagy, accessible to its members, associate members as well as to a group of international affiliate members. It provides a mentoring structure for support of junior faculty enrolled with the center and promotes collaborative multidisciplinary studies centered on the key thematic focus of the AIM center – fundamental study of autophagy and its role in disease. The AIM has International Council of Affiliate Members on all continents.[2] The center hosts annual meetings and workshops with national and international reach and impact. The AIM center leads and supports cutting edge research, including supporting research pilots https://www.autophagy.center/node/443 for Covid / coronavirus pandemic crisis.
References
- ↑ "Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations". Autophagy 14 (6): 925–929. 2018-06-23. doi:10.1080/15548627.2018.1465784. PMID 29938597.
- ↑ 2.0 2.1 "Autophagy, Inflammation, and Metabolism (AIM) Center in its second year". Autophagy 15 (10): 1829–1833. October 2019. doi:10.1080/15548627.2019.1634444. PMID 31234750.
- ↑ Vojo, Deretic. "Autophagy, Inflammation and Metabolism (AIM) in Disease Center" (in en). Grantome. http://grantome.com/grant/NIH/P20-GM121176-01.
External links
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