Chemistry:SIB-1893

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Short description: Chemical compound
SIB-1893
SIB-1893.svg
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC14H13N
Molar mass195.265 g·mol−1
3D model (JSmol)
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SIB-1893 is a drug used in scientific research which was one of the first compounds developed that acts as a selective antagonist for the metabotropic glutamate receptor subtype mGluR5.[1] It has anticonvulsant and neuroprotective effects,[2] and reduces glutamate release.[3] It has also been found to act as a positive allosteric modulator of mGluR4.[4]

References

  1. "SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5". The Journal of Pharmacology and Experimental Therapeutics 290 (1): 170–81. July 1999. PMID 10381773. 
  2. "Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893)". Neuropharmacology 39 (9): 1567–74. July 2000. doi:10.1016/S0028-3908(99)00242-7. PMID 10854901. 
  3. "Noncompetitive metabotropic glutamate5 receptor antagonist (E)-2-methyl-6-styryl-pyridine (SIB1893) depresses glutamate release through inhibition of voltage-dependent Ca2+ entry in rat cerebrocortical nerve terminals (synaptosomes)". The Journal of Pharmacology and Experimental Therapeutics 309 (3): 951–8. June 2004. doi:10.1124/jpet.103.064881. PMID 14982967. 
  4. "Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP". British Journal of Pharmacology 138 (6): 1026–30. March 2003. doi:10.1038/sj.bjp.0705159. PMID 12684257.