Chemistry:Oxyclozanide
From HandWiki
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| Preferred IUPAC name
2,3,5-Trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide | |
| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
| KEGG | |
PubChem CID
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| Properties | |
| C13H6Cl5NO3 | |
| Molar mass | 401.45 g·mol−1 |
| Pharmacology | |
| 1=ATCvet code} | QP52AG06 (WHO) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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| Infobox references | |
Oxyclozanide is a salicylanilide anthelmintic. It is used in the treatment and control of fascioliasis in ruminants mainly domestic animals such as cattle, sheep, and goats. It mainly acts by uncoupling of oxidative phosphorylation in flukes.[1] Along with niclosamide, another tapeworm drug, it has been recently found to display "strong in vivo and in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA)".[2]
Sometimes alluded to as "Pentaclosamide": CN101891646.
References
- ↑ CID 16779 from PubChem
- ↑ Rajamuthiah, Rajmohan; Fuchs, Beth Burgwyn; Conery, Annie L.; Kim, Wooseong; Jayamani, Elamparithi; Kwon, Bumsup; Ausubel, Frederick M.; Mylonakis, Eleftherios (2015). "Repurposing Salicylanilide Anthelmintic Drugs to Combat Drug Resistant Staphylococcus aureus". PLOS ONE 10 (4): e0124595. doi:10.1371/journal.pone.0124595. PMID 25897961. Bibcode: 2015PLoSO..1024595R.
- ↑ Oxyclozanide MSDS
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