Chemistry:Nufenoxole
From HandWiki
Short description: Chemical compound
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| Formula | C25H29N3O |
| Molar mass | 387.527 g·mol−1 |
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Nufenoxole (SC-27166) is an antidiarrhoeal drug which acts as a peripherally selective opioid agonist, in a similar manner to loperamide. while it is able to activate μ-opioid receptors, it fails to cross the blood–brain barrier and so has a selective action against diarrhoea without producing analgesic effects.[1][2][3][4][5]
See also
References
- ↑ Adelstein GW, "1,1-Diaryl-1-oxadiazol-alkylamines", US patent RE29556E, issued 28 February 1978, assigned to G.D. Searle & Company
- ↑ "The pharmacology of SC-27166: a novel antidiarrheal agent". The Journal of Pharmacology and Experimental Therapeutics 203 (3): 512–26. December 1977. PMID 411912.
- ↑ "Antidiarrheal and central nervous system activities of SC-27166 (2-[3 - 5 - methyl - 1, 3, 4 - oxadiazol - 2 - yl) - 3, 3 - diphenylpropyl] - 2 - azabicyclo [2.2.2]octane), a new antidiarrheal agent, resulting from binding to opiate receptor sites of brain and myenteric plexus". The Journal of Pharmacology and Experimental Therapeutics 203 (3): 527–38. December 1977. PMID 200732.
- ↑ "Dissociation between opiate-like and antidiarrheal activities of antidiarrheal drugs". The Journal of Pharmacology and Experimental Therapeutics 210 (3): 327–33. September 1979. PMID 480185.
- ↑ "Dependence liability of two antidiarrheals, nufenoxole and loperamide". Clinical Pharmacology and Therapeutics 27 (5): 659–64. May 1980. doi:10.1038/clpt.1980.93. PMID 7371363.
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