Chemistry:Cipralisant
 | |
| Clinical data | |
|---|---|
| ATC code |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C14H20N2 |
| Molar mass | 216.328 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  (what is this?) (verify) | |
Cipralisant (GT-2331, tentative trade name Perceptin) is an extremely potent histamine H3 receptor ligand originally developed by Gliatech.[1] Cipralisant was initially classified as a selective H3 antagonist,[2] but newer research (2005) suggests also agonist properties, i.e., functional selectivity.[3]
The relatively recent cloning of human H3 receptor, as well as the discovery of its constitutive activity provided the ability to better assess the activity of H3 receptor ligands. Consequently, cipralisant was reassessed as an H3 receptor agonist in human and rat recombinant systems, showing functional selectivity and stimulating one type of G-protein coupled pathway while failing to activate other intracellular pathways.[3]
Gliatech filed for bankruptcy in 2002, and its intellectual property was inherited by Merck. The development of cipralisant seems to have been suspended since 2003 but research is ongoing, and recently it has been shown that it is the (1S,2S)-enantiomer which is the biologically active one.[4]
References
- ↑ "Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor". European Journal of Pharmacology 529 (1–3): 40–46. January 2006. doi:10.1016/j.ejphar.2005.10.066. PMID 16316645.
- ↑ "High antagonist potency of GT-2227 and GT-2331, new histamine H3 receptor antagonists, in two functional models". European Journal of Pharmacology 351 (3): 307–311. June 1998. doi:10.1016/S0014-2999(98)00396-3. PMID 9721022.
- ↑ 3.0 3.1 "G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations". The Journal of Pharmacology and Experimental Therapeutics 314 (1): 271–281. July 2005. doi:10.1124/jpet.104.078865. PMID 15821027.
- ↑ "An efficient multigram synthesis of the potent histamine H3 antagonist GT-2331 and the reassessment of the absolute configuration". The Journal of Organic Chemistry 69 (1): 192–194. January 2004. doi:10.1021/jo035264t. PMID 14703397.
 |  |
