Biology:UQCR11
 Generic protein structure example |
UQCR11 (ubiquinol-cytochrome c reductase, complex III sub-unit XI) is a protein that in humans is encoded by the UQCR11 gene.[1][2] UQCR11 is the smallest known component of Complex III in the mitochondrial respiratory chain.[2]
Structure
The UQCR11 gene, located on the p arm of chromosome 19 in position 13.3, is made up of 3 exons and is 8,329 base pairs in length.[2] The UQCR11 protein weighs 6.6 kDa and is composed of 56 amino acids.[3][4] This gene encodes the smallest known component of the ubiquinol-cytochrome c reductase complex, which is also known as Complex III and is part of the mitochondrial respiratory chain.[2] In vertebrates, Complex III contains 11 sub-units: 3 respiratory sub-units, 2 core proteins and 6 low-molecular weight proteins.[5][6] Proteobacterial complexes may contain as few as three sub-units.[7]
Function
The UQCR11 protein may function as a binding factor for the iron-sulfur protein in Complex III, which is ubiquitous in human cells.[2] Complex III catalyzes the chemical reaction
- QH2 + 2 ferricytochrome c [math]\displaystyle{ \rightleftharpoons }[/math] Q + 2 ferrocytochrome c + 2 H+
Thus, the two substrates of Complex III are dihydroquinone (QH2) and ferri- (Fe3+) cytochrome c, whereas its 3 products are quinone (Q), ferro- (Fe2+) cytochrome c, and H+. This complex belongs to the family of oxidoreductases, specifically those acting on diphenols and related substances as donor with a cytochrome as acceptor. This enzyme participates in oxidative phosphorylation. It has four cofactors: cytochrome c1, cytochrome b-562, cytochrome b-566 and a 2-Iron ferredoxin of the Rieske type.
References
- ↑ "Human housekeeping genes are compact". Trends in Genetics 19 (7): 362–365. July 2003. doi:10.1016/S0168-9525(03)00140-9. PMID 12850439. Bibcode: 2003q.bio.....9020E.
- ↑ 2.0 2.1 2.2 2.3 2.4 "Entrez Gene: UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI". https://www.ncbi.nlm.nih.gov/gene/10975?ordinalpos=7&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum.
- ↑ "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research 113 (9): 1043–53. Oct 2013. doi:10.1161/CIRCRESAHA.113.301151. PMID 23965338.
- ↑ "Cytochrome b-c1 complex subunit 11". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). https://amino.heartproteome.org/web/protein/O14957.
- ↑ "Electron transfer by domain movement in cytochrome bc1.". Nature 392 (6677): 677–84. 1998. doi:10.1038/33612. PMID 9565029. Bibcode: 1998Natur.392..677Z. https://pubmed.ncbi.nlm.nih.gov/9565029.
- ↑ "Computational discovery of picomolar Q(o) site inhibitors of cytochrome bc1 complex.". J Am Chem Soc 134 (27): 11168–76. 2012. doi:10.1021/ja3001908. PMID 22690928. https://pubmed.ncbi.nlm.nih.gov/22690928.
- ↑ "Purification of a three-subunit ubiquinol-cytochrome c oxidoreductase complex from Paracoccus denitrificans". J Biol Chem 261 (26): 12282–9. 1986. doi:10.1016/S0021-9258(18)67236-9. PMID 3017970.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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