Biology:TRPC6
 Generic protein structure example |
Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name. TRPC6 is a transient receptor potential channel of the classical TRPC subfamily. It has been associated with depression and anxiety (see below), as well as with focal segmental glomerulosclerosis (FSGS).[1]
Interactions
TRPC6 has been shown to interact with:
Ligands
Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum, also known as St. John's Wort, are hyperforin and adhyperforin.[5][6] These compounds are inhibitors of the reuptake of serotonin, norepinephrine, dopamine, γ-aminobutyric acid, and glutamate, and they are reported to exert these effects by binding to and activating TRPC6.[6][7] Recent results with hyperforin have cast doubt on these findings as similar currents are seen upon Hyperforin treatment regardless of the presence of TRPC6.[8]
References
- ↑ "A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis". Science 308 (5729): 1801–4. June 2005. doi:10.1126/science.1106215. PMID 15879175.
- ↑ "Regulation of TRPC6 channel activity by tyrosine phosphorylation". The Journal of Biological Chemistry 279 (18): 18887–94. April 2004. doi:10.1074/jbc.M311274200. PMID 14761972.
- ↑ "Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx". The Journal of Biological Chemistry 279 (11): 10514–22. March 2004. doi:10.1074/jbc.M308478200. PMID 14699131.
- ↑ "Subunit composition of mammalian transient receptor potential channels in living cells". Proceedings of the National Academy of Sciences of the United States of America 99 (11): 7461–6. May 2002. doi:10.1073/pnas.102596199. PMID 12032305.
- ↑ "Hyperforin--antidepressant activity by a novel mechanism of action". Pharmacopsychiatry 34 (Suppl 1): S98-102. July 2001. doi:10.1055/s-2001-15512. PMID 11518085.
- ↑ 6.0 6.1 "Hyperforin as a possible antidepressant component of hypericum extracts". Life Sciences 63 (6): 499–510. 1998. doi:10.1016/S0024-3205(98)00299-9. PMID 9718074.
- ↑ "Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels". FASEB Journal 21 (14): 4101–11. December 2007. doi:10.1096/fj.07-8110com. PMID 17666455.
- ↑ "Protonophore properties of hyperforin are essential for its pharmacological activity". Scientific Reports 4: 7500. December 2014. doi:10.1038/srep07500. PMID 25511254.
Further reading
- "Role and regulation of TRP channels in neutrophil granulocytes". Cell Calcium 33 (5–6): 533–40. 2004. doi:10.1016/S0143-4160(03)00058-7. PMID 12765698.
- "Slit or pore? A mutation of the ion channel TRPC6 causes FSGS". Nephrology, Dialysis, Transplantation 20 (9): 1777–9. September 2005. doi:10.1093/ndt/gfh961. PMID 15998650.
- "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews 57 (4): 427–50. December 2005. doi:10.1124/pr.57.4.6. PMID 16382100.
- "TRPC6 in glomerular health and disease: what we know and what we believe". Seminars in Cell & Developmental Biology 17 (6): 667–74. December 2006. doi:10.1016/j.semcdb.2006.11.003. PMID 17116414.
- "TRPC6". Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology. 179. 2007. pp. 125–41. doi:10.1007/978-3-540-34891-7_7. ISBN 978-3-540-34889-4.
External links
- TRPC6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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