Biology:RENBP
From HandWiki
Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
N-acylglucosamine 2-epimerase is an enzyme that in humans is encoded by the RENBP gene.[1][2]
The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature.[2]
References
- ↑ "The human gene for renin-binding protein". J Biol Chem 267 (18): 13007–13. Aug 1992. doi:10.1016/S0021-9258(18)42374-5. PMID 1618798.
- ↑ 2.0 2.1 "Entrez Gene: RENBP renin binding protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5973.
Further reading
- "Genetic and molecular properties of human and rat renin-binding proteins with reference to the function of the leucine zipper motif". J. Biochem. 110 (4): 493–500. 1992. doi:10.1093/oxfordjournals.jbchem.a123609. PMID 1723410.
- "A study on renin binding protein (RnBP) in the human kidney". J. Biochem. 97 (2): 671–7. 1985. doi:10.1093/oxfordjournals.jbchem.a135103. PMID 3924907.
- "Properties of renin-binding protein". Clinical and Experimental Hypertension, Part A 4 (11–12): 2073–81. 1983. doi:10.3109/10641968209062372. PMID 6756682.
- "The human genes encoding renin-binding protein and host cell factor are closely linked in Xq28 and transcribed in the same direction". Gene 155 (2): 237–9. 1995. doi:10.1016/0378-1119(94)00810-F. PMID 7721097.
- "The human renin-binding protein gene (RENBP) maps in Xq28". Genomics 21 (1): 279–81. 1994. doi:10.1006/geno.1994.1259. PMID 8088804.
- "Human renin binding protein: complete genomic sequence and association of an intronic T/C polymorphism with the prorenin level in males". Hum. Mol. Genet. 6 (9): 1527–34. 1998. doi:10.1093/hmg/6.9.1527. PMID 9285790.
- "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics 44 (1): 8–14. 1997. doi:10.1006/geno.1997.4822. PMID 9286695.
- "A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase". J. Biol. Chem. 272 (39): 24319–24. 1997. doi:10.1074/jbc.272.39.24319. PMID 9305888.
- "Human renin-binding protein is the enzyme N-acetyl-D-glucosamine 2-epimerase". J. Biochem. 125 (2): 348–53. 1999. doi:10.1093/oxfordjournals.jbchem.a022293. PMID 9990133.
- "Renin inhibits N-acetyl-D-glucosamine 2-epimerase (renin-binding protein)". J. Biochem. 128 (6): 951–6. 2001. doi:10.1093/oxfordjournals.jbchem.a022846. PMID 11098137.
- "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. 2001. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- "Expression of renin-angiotensin system genes in immature and mature dendritic cells identified using human cDNA microarray". Biochem. Biophys. Res. Commun. 285 (4): 1059–65. 2001. doi:10.1006/bbrc.2001.5215. PMID 11467860.
- "Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine 2-epimerase (Renin binding protein)". J. Biochem. 131 (4): 605–10. 2002. doi:10.1093/oxfordjournals.jbchem.a003140. PMID 11926999.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism". J. Biol. Chem. 278 (10): 8035–42. 2003. doi:10.1074/jbc.M212127200. PMID 12499362. https://digital.library.unt.edu/ark:/67531/metadc784810/.
- "Selective activation of N-acyl-D-glucosamine 2-epimerase expression in failing human heart ventricular myocytes". J. Card. Fail. 9 (1): 59–68. 2003. doi:10.1054/jcaf.2003.6. PMID 12612874.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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