Biology:Nfat activating protein with itam motif 1
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 Generic protein structure example |
NFAT activating protein with ITAM motif 1 is a protein that in humans is encoded by the NFAM1 gene.
[1]
Function
The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008].
References
Further reading
- "Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway". J. Biol. Chem. 278 (19): 16797–801. May 2003. doi:10.1074/jbc.M211060200. PMID 12615919.
- "Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation". Am. J. Physiol., Cell Physiol. 292 (3): C1167–78. March 2007. doi:10.1152/ajpcell.00590.2005. PMID 17079331. http://portal.research.lu.se/ws/files/4923025/625765.pdf.
- "Nuclear factor of activated T-cells (NFAT) plays a role in SV40 infection". Virology 372 (1): 48–55. March 2008. doi:10.1016/j.virol.2007.10.029. PMID 18031784.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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