Biology:NLRP7
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
NACHT, LRR and PYD domains-containing protein 7 is a protein that in humans is encoded by the NLRP7 gene.[1][2][3]
Function
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP7, have an N-terminal pyrin (MEFV) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes.[3]
References
- ↑ "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol 4 (2): 95–104. Feb 2003. doi:10.1038/nrm1019. PMID 12563287.
- ↑ "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J Biol Chem 277 (33): 29874–80. Aug 2002. doi:10.1074/jbc.M203915200. PMID 12019269.
- ↑ 3.0 3.1 "Entrez Gene: NLRP7 NLR family, pyrin domain containing 7". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=199713.
Further reading
- "NODs: intracellular proteins involved in inflammation and apoptosis.". Nat. Rev. Immunol. 3 (5): 371–82. 2003. doi:10.1038/nri1086. PMID 12766759.
- "Genetic mapping of a maternal locus responsible for familial hydatidiform moles.". Hum. Mol. Genet. 8 (4): 667–71. 1999. doi:10.1093/hmg/8.4.667. PMID 10072436.
- "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.". FEBS Lett. 530 (1–3): 73–8. 2002. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. 2004. doi:10.1038/nature02399. PMID 15057824. Bibcode: 2004Natur.428..529G.
- "Oncogenic role of NALP7 in testicular seminomas.". Cancer Sci. 95 (12): 949–54. 2005. doi:10.1111/j.1349-7006.2004.tb03182.x. PMID 15596043.
- "PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion.". J. Biol. Chem. 280 (23): 21720–5. 2005. doi:10.1074/jbc.M410057200. PMID 15817483.
- "Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans.". Nat. Genet. 38 (3): 300–2. 2006. doi:10.1038/ng1740. PMID 16462743.
- "Genetics and epigenetics of hydatidiform moles.". Nat. Genet. 38 (3): 274–6. 2006. doi:10.1038/ng0306-274. PMID 16501554.
- "Familial molar tissues due to mutations in the inflammatory gene, NALP7, have normal postzygotic DNA methylation.". Hum. Genet. 120 (3): 390–5. 2007. doi:10.1007/s00439-006-0192-3. PMID 16874523. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=132466.
- "Women heterozygous for NALP7/NLRP7 mutations are at risk for reproductive wastage: report of two novel mutations.". Hum. Mutat. 28 (7): 741. 2007. doi:10.1002/humu.9498. PMID 17579354.
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