Biology:Matrix metalloproteinase inhibitor
From HandWiki
A matrix metalloproteinase inhibitor (MMPI, INN stem –mastat[1]) inhibits matrix metalloproteinases. Because they inhibit cell migration, they have antiangiogenic effects. They may be both endogenous and exogenous.
The most notorious endogenous metalloproteinases are tissue inhibitors of metalloproteinases (TIMPs). There are also cartilage-derived angiogenesis inhibitors.
Exogenous matrix metalloproteinase inhibitors were developed as anticancer drugs.[2] Examples include:
- Batimastat
- Cipemastat
- Ilomastat
- Marimastat
- MMI270
- Prinomastat
- Rebimastat
- Ro 28-2653
- Tanomastat
Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalopods, mollusks, algae, and bacteria.[3]
See also
- Drug discovery and development of MMP inhibitors
References
- ↑ "The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances". World Health Organization. https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/stembook-2018.pdf.
- ↑ Coussens, L. M. (2002). "Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations". Science 295 (5564): 2387–2392. doi:10.1126/science.1067100. ISSN 0036-8075. PMID 11923519. Bibcode: 2002Sci...295.2387C.
- ↑ Noel Vinay Thomas; Se Kwon Kim (2010). "Metalloproteinase Inhibitors Stts and Scope from Marine Organisms". Biochemistry Research International 2010: 845975. doi:10.1155/2010/845975. PMID 21197102.
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